Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2017.10.023
Abstract: Abstract We produced 8 lines of transgenic (Tg) rats expressing one of two different rhodopsin mutations in albino Sprague‐Dawley (SD) rats. Three lines were generated with a proline to histidine substitution at codon 23 (P23H),… read more here.
Keywords: p23h; rhodopsin; s334ter; degeneration ... See more keywords
Experimental mammary carcinogenesis ‐ Rat models
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.02.004
Abstract: &NA; Mammary cancer is one of the most common cancers, victimizing more than half a million of women worldwide every year. Despite all the studies in this field, the current therapeutic approaches are not effective… read more here.
Keywords: carcinogenesis rat; mammary carcinogenesis; rat models; experimental mammary ... See more keywords
Duloxetine ameliorates the impairment of diffuse noxious inhibitory control in rat models of peripheral neuropathic pain and knee osteoarthritis pain
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134990
Abstract: Diffuse noxious inhibitory control (DNIC) is a phenomenon to reflect descending pain modulation in animals. Conditioned pain modulation (CPM) is the human counterpart of DNIC and is reduced in patients with several chronic pain conditions.… read more here.
Keywords: pwt; peripheral neuropathic; duloxetine; neuropathic pain ... See more keywords
Dysregulation of miR-185, miR-193a, and miR-450a in the skin are linked to the depressive phenotype
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.110052
Abstract: BACKGROUND Dysregulated micro-RNAs (miRNAs) in dermal fibroblasts of depressive subjects, indicate biomarker potential and can possibly aid clinical diagnostics. To overcome methodological challenges related to human experiments and fibroblast cultures, we here validate 38 miRNAs… read more here.
Keywords: mir 450a; mir 185; mir; dysregulation ... See more keywords
Different sites of actions make different responses to thiazolidinediones between mouse and rat models of fatty liver
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-021-04036-7
Abstract: Therapeutic approach for NAFLD is limited and there are no approved drugs. Pioglitazone (PGZ), a thiazolidinedione (TZD) that acts via peroxisome proliferator activated receptor gamma (PPAR γ ) is the only agent that has shown… read more here.
Keywords: lep mkyo; mouse models; mice; fatty liver ... See more keywords
Silencing of GAS5 alleviates glaucoma in rat models by reducing retinal ganglion cell apoptosis.
Sign Up to like & getrecommendations! Published in 2019 at "Human gene therapy"
DOI: 10.1089/hum.2019.056
Abstract: OBJECTIVE Retinal ganglion cells (RGCs) play a key role in the pathogenesis and development of glaucoma. The present study aims to investigate the underlying mechanism of long non-coding RNA (lncRNA) GAS5 in glaucoma development through… read more here.
Keywords: apoptosis; gas5; retinal ganglion; cell apoptosis ... See more keywords
MiR‐101 promotes pain hypersensitivity in rats with chronic constriction injury via the MKP‐1 mediated MAPK pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15532
Abstract: This study was performed to characterize the effect of microRNA‐101 (miR‐101) on the pain hypersensitivity in CCI rat models with the involvement of mitogen‐activated protein kinase phosphatase 1 (MKP‐1) in spinal cord microglial cells. The… read more here.
Keywords: pain hypersensitivity; mir 101; cci rat; hypersensitivity ... See more keywords
Abstract B37: Understanding DCIS initiation and progression using PDX and genetically engineered mouse and rat models
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.camodels2020-b37
Abstract: Ductal carcinoma in situ (DCIS) is a starting lesion in the milk duct of the breast, which accounts for 25% of all “breast cancers” detected. DCIS is usually treated by surgery combined with radiotherapy, which… read more here.
Keywords: genetically engineered; engineered mouse; dcis; progression ... See more keywords
Additional dexamethasone in chemotherapies with carboplatin and paclitaxel could reduce the impaired glycometabolism in rat models
Sign Up to like & getrecommendations! Published in 2017 at "BMC Cancer"
DOI: 10.1186/s12885-017-3917-x
Abstract: BackgroundSide-effects have been considered as the limitation of the chemotherapy agents’ administration and life quality in patients with ovarian cancers. In order to explore the influence of the chemotherapy agents commonly used in ovarian cancer… read more here.
Keywords: glucose levels; group; dexamethasone; day ... See more keywords
The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-020-01932-y
Abstract: Background Osteoarthritis (OA), though being treated via various methods and medicines, is still a major healthcare concern mostly due to the increase in diagnosis of these age-related diseases. The present study aimed at investigating the… read more here.
Keywords: seed; male rat; grape seed; rat models ... See more keywords
Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinology"
DOI: 10.1210/en.2016-1665
Abstract: Hypothalamic lesions or deficient melanocortin (MC) signaling via MC4 receptor (MC4r) mutations often lead to hyperphagia and severe treatment-resistant obesity. We tested the methionine aminopeptidase 2-inhibitor beloranib (ZGN-440) in 2 male rat models of obesity,… read more here.
Keywords: treatment; zgn 440; hypothalamic obesity; excess weight ... See more keywords