Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2017.10.023
Abstract: Abstract We produced 8 lines of transgenic (Tg) rats expressing one of two different rhodopsin mutations in albino Sprague‐Dawley (SD) rats. Three lines were generated with a proline to histidine substitution at codon 23 (P23H),… read more here.
Keywords: p23h; rhodopsin; s334ter; degeneration ... See more keywords
Experimental mammary carcinogenesis ‐ Rat models
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.02.004
Abstract: &NA; Mammary cancer is one of the most common cancers, victimizing more than half a million of women worldwide every year. Despite all the studies in this field, the current therapeutic approaches are not effective… read more here.
Keywords: carcinogenesis rat; mammary carcinogenesis; rat models; experimental mammary ... See more keywords
Duloxetine ameliorates the impairment of diffuse noxious inhibitory control in rat models of peripheral neuropathic pain and knee osteoarthritis pain
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134990
Abstract: Diffuse noxious inhibitory control (DNIC) is a phenomenon to reflect descending pain modulation in animals. Conditioned pain modulation (CPM) is the human counterpart of DNIC and is reduced in patients with several chronic pain conditions.… read more here.
Keywords: pwt; peripheral neuropathic; duloxetine; neuropathic pain ... See more keywords
Dysregulation of miR-185, miR-193a, and miR-450a in the skin are linked to the depressive phenotype
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.110052
Abstract: BACKGROUND Dysregulated micro-RNAs (miRNAs) in dermal fibroblasts of depressive subjects, indicate biomarker potential and can possibly aid clinical diagnostics. To overcome methodological challenges related to human experiments and fibroblast cultures, we here validate 38 miRNAs… read more here.
Keywords: mir 450a; mir 185; mir; dysregulation ... See more keywords
Different sites of actions make different responses to thiazolidinediones between mouse and rat models of fatty liver
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-021-04036-7
Abstract: Therapeutic approach for NAFLD is limited and there are no approved drugs. Pioglitazone (PGZ), a thiazolidinedione (TZD) that acts via peroxisome proliferator activated receptor gamma (PPAR γ ) is the only agent that has shown… read more here.
Keywords: lep mkyo; mouse models; mice; fatty liver ... See more keywords
Silencing of GAS5 alleviates glaucoma in rat models by reducing retinal ganglion cell apoptosis.
Sign Up to like & getrecommendations! Published in 2019 at "Human gene therapy"
DOI: 10.1089/hum.2019.056
Abstract: OBJECTIVE Retinal ganglion cells (RGCs) play a key role in the pathogenesis and development of glaucoma. The present study aims to investigate the underlying mechanism of long non-coding RNA (lncRNA) GAS5 in glaucoma development through… read more here.
Keywords: apoptosis; gas5; retinal ganglion; cell apoptosis ... See more keywords
MiR‐101 promotes pain hypersensitivity in rats with chronic constriction injury via the MKP‐1 mediated MAPK pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15532
Abstract: This study was performed to characterize the effect of microRNA‐101 (miR‐101) on the pain hypersensitivity in CCI rat models with the involvement of mitogen‐activated protein kinase phosphatase 1 (MKP‐1) in spinal cord microglial cells. The… read more here.
Keywords: pain hypersensitivity; mir 101; cci rat; hypersensitivity ... See more keywords
Abatacept: A Promising Repurposed Solution for Myocardial Infarction-Induced Inflammation in Rat Models
Sign Up to like & getrecommendations! Published in 2024 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2024/3534104
Abstract: Myocardial infarction (MI) is irreversible damage to the myocardial tissue caused by prolonged ischemia/hypoxia, subsequently leading to loss of contractile function and myocardial damage. However, after a perilous period, ischemia-reperfusion (IR) itself causes the generation… read more here.
Keywords: rat models; abt; abatacept promising; myocardial infarction ... See more keywords
Abstract B37: Understanding DCIS initiation and progression using PDX and genetically engineered mouse and rat models
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.camodels2020-b37
Abstract: Ductal carcinoma in situ (DCIS) is a starting lesion in the milk duct of the breast, which accounts for 25% of all “breast cancers” detected. DCIS is usually treated by surgery combined with radiotherapy, which… read more here.
Keywords: genetically engineered; engineered mouse; dcis; progression ... See more keywords
Protective Role of Jimson Weed in Mitigating Dyslipidemia, Cardiovascular, and Renal Dysfunction in Diabetic Rat Models: In Vivo and in Silico Evidence
Sign Up to like & getrecommendations! Published in 2024 at "Natural Product Communications"
DOI: 10.1177/1934578x241299279
Abstract: Background Diabetes mellitus (DM) is characterized by irregular carbohydrate, protein, and fat metabolism, leading to elevated blood glucose levels. DM patients are at a high risk of developing dyslipidemia and cardiovascular and chronic kidney diseases.… read more here.
Keywords: rat models; dyslipidemia cardiovascular; rats class; jimson weed ... See more keywords
Genome-wide characterization of circular RNAs in three rat models of pulmonary hypertension reveals distinct pathological patterns
Sign Up to like & getrecommendations! Published in 2025 at "BMC Genomics"
DOI: 10.1186/s12864-025-11239-z
Abstract: Pulmonary hypertension (PH) is a devastating disease marked by elevated pulmonary artery pressure, resulting in right ventricular (RV) failure and mortality. Despite the identification of several dysregulated genes in PH, the involvement of circular RNAs… read more here.
Keywords: rat models; genome wide; pulmonary hypertension; three rat ... See more keywords