In utero exposure to atypical antipsychotic drug, risperidone: Effects on fetal neurotoxicity in hippocampal region and cognitive impairment in rat offspring
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2016.12.006
Abstract: ABSTRACT Clinical studies indicate that about one‐third of pregnant women with psychotic symptoms are exposed to either typical or atypical antipsychotic drugs (APDs). Reports on prenatal subject/model are lacking hence, the present study was undertaken… read more here.
Keywords: rat offspring; atypical antipsychotic; exposure; study ... See more keywords
Effects of maternal immune activation on brain arginine metabolism of postnatal day 2 rat offspring
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2017.05.016
Abstract: l-Arginine is a versatile semi-essential amino acid with a number of bioactive metabolites, and altered arginine metabolism has been implicated in the pathogenesis of schizophrenia. Earlier research has demonstrated that maternal immune activation (MIA; a… read more here.
Keywords: immune activation; maternal immune; metabolism; rat offspring ... See more keywords
Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Developmental Origins of Health and Disease"
DOI: 10.1017/s2040174416000702
Abstract: Based on the Developmental Origin of Health and Disease concept, maternal undernutrition has been shown to sensitize adult offspring to metabolic pathologies such as obesity. Using a model of maternal 70% food restriction in pregnant… read more here.
Keywords: adult; male rat; maternal undernutrition; rat offspring ... See more keywords
Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0437-z
Abstract: Intrauterine hypoxia (IUH) affects the growth and development of offspring. It remains unclear that how long the impact of IUH on cognitive function lasts and whether sexual differences exist. Spermidine (SPD) has shown to improve… read more here.
Keywords: intervention; rat offspring; iuh; cognitive function ... See more keywords
Ameliorating effect of leukotriene receptor antagonist in multi-organ toxicity induced in rat offspring, a possible role for epidermal growth factor
Sign Up to like & getrecommendations! Published in 2021 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2021.1878213
Abstract: Abstract Purpose: Nowadays, there is a dramatic increase in the interest of potential impact of consumer-relevant engineered nanoparticles on pregnancy. Materials and methods: This study investigated the possible protective effect of montelukast in neonatal organ… read more here.
Keywords: toxicity induced; rat offspring; possible role; growth factor ... See more keywords
Maternal diet supplemented with African walnuts enhances cortico-hippocampal gene expression and histomorphology in rat offspring.
Sign Up to like & getrecommendations! Published in 2023 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2023.2166804
Abstract: BACKGROUND The brain is built up during pregnancy. How it functions afterwards depends on how the expectant mother's diet nourishes it. Walnuts contain significant quantities of polyunsaturated fatty acids (PUFAs) and bioactive phytochemicals, which enhance… read more here.
Keywords: african walnuts; brain; expression; rat offspring ... See more keywords
Mitochondrial KATP channels contribute to the protective effects of hydrogen sulfide against impairment of central chemoreception of rat offspring exposed to maternal cigarette smoke
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0237643
Abstract: We previously reported that maternal cigarette smoke (CS) exposure resulted in impairment of central chemoreception and induced mitochondrial dysfunction in offspring parafacial respiratory group (pFRG), the kernel for mammalian central chemoreception. We also found that… read more here.
Keywords: central chemoreception; rat offspring; chemoreception; impairment central ... See more keywords
Prenatal caffeine damaged learning and memory in rat offspring mediated by ARs/PKA/CREB/BDNF pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Physiological research"
DOI: 10.33549/physiolres.933906
Abstract: Prenatal exposure to caffeine can cause developmental problems. This study determined chronic influence of prenatal caffeine at relatively higher doses on cognitive functions in the rat offspring. Pregnant Sprague-Dawley rats (4-month-old) were exposed to caffeine… read more here.
Keywords: rat offspring; caffeine; learning memory; prenatal caffeine ... See more keywords
Maternal Protein Restriction Alters the Expression of Proteins Related to the Structure and Functioning of the Rat Offspring Epididymis in an Age-Dependent Manner
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.816637
Abstract: Nutrition is an environmental factor able to activate physiological interactions between fetus and mother. Maternal protein restriction is able to alter sperm parameters associated with epididymal functions. Since correct development and functioning of the epididymides… read more here.
Keywords: age dependent; rat offspring; maternal protein; protein restriction ... See more keywords
Maternal Exposure to Acephate Caused Nephrotoxicity in Adult Offspring Rats Mediated by Excessive Autophagy Activation, Oxidative Stress Induction, and Altered Epithelial Sodium Channel and Na+/K+-ATPase Gene Expression
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12020162
Abstract: Simple Summary Although continuous exposure to conventional pesticides has been linked to tissue dysfunction among humans and animals, there is little information regarding the environmental disturbances and their harmful effects on fetuses. In the present… read more here.
Keywords: exposure acephate; oxidative stress; rat offspring; acephate ... See more keywords
Alteration of the Early Development Environment by Maternal Diet and the Occurrence of Autistic-like Phenotypes in Rat Offspring
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22189662
Abstract: Epidemiological and preclinical studies suggest that maternal obesity increases the risk of autism spectrum disorder (ASD) in offspring. Here, we assessed the effects of exposure to modified maternal diets limited to pregnancy and lactation on… read more here.
Keywords: early development; development environment; rat offspring; environment maternal ... See more keywords