A validated LC-MS/MS method for the simultaneous determination of 20-(S)-protopanaxatriol and its two active metabolites in rat plasma: Application to a pharmacokinetics study.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of separation science"
DOI: 10.1002/jssc.201700909
Abstract: We present a validated liquid chromatography with tandem mass spectrometry method for simultaneous determination of 20-(S)-protopanaxatriol and its two oxidative stereoisomeric metabolites (20S,24S)-epoxy-dammarane-3,6,12,25-tetraol (M1) and (20S,24R)-epoxy-dammarane-3,6,12,25-tetraol (M2) in rat plasma. 20-(S)-Protopanaxatriol, M1, and M2 were… read more here.
Keywords: simultaneous determination; rat plasma; protopanaxatriol two; method simultaneous ... See more keywords
Global characterization of chemical compounds in Shidan granule and their metabolites in rat plasma using ultra-high-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200391
Abstract: Shidan granule is an in-hospital traditional Chinese medicines prescription with obvious clinical effect in the treatment of chronic atrophic gastritis. Charactering the compounds of Shidan granule and exploring the absorbed prototype constituents and metabolites in… read more here.
Keywords: compounds shidan; ultra high; rat plasma; shidan granule ... See more keywords
Synthesis, characterization, and application of griseofulvin surface molecularly imprinted polymers as the selective solid phase extraction sorbent in rat plasma samples
Sign Up to like & getrecommendations! Published in 2020 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2019.06.007
Abstract: Abstract In present study, an investigation was carried out to develop and validate an analytical method for the selective extraction and determination of griseofulvin (GSF) from plasma samples. For this purpose, a rational approach was… read more here.
Keywords: plasma samples; method; rat plasma; extraction ... See more keywords
O13 Quantitative analysis of an oil based natural compound extracted from plasma
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.06.078
Abstract: The ability to measure concentrations of a molecule underpins the building of a comprehensive knowledge of the pharmacokinetics of a pharmaceutical or nutraceutical, which is essential for the determination of its safety and efficacy. In… read more here.
Keywords: molecule; rat plasma; analysis; quantitative analysis ... See more keywords
Pharmacokinetics and comparative metabolic profiling of iridoid enriched fraction of Picrorhiza kurroa - An Ayurvedic Herb.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2016.07.072
Abstract: ETHNO-PHARMACOLOGICAL RELEVANCE Picrosides I, II and apocynin are the main active principles present in the roots and rhizomes of Picrorhiza kurroa Royle ex. Benth (Kutki). Ethno-medicinally, the plant is used for the treatment of liver,… read more here.
Keywords: rat plasma; metabolic profiling; enriched fraction; picrosides apocynin ... See more keywords
Simultaneous determination and pharmacokinetic study of four phenolic acids in rat plasma using UFLC–MS/MS after intravenous administration of salvianolic acid for injection
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.10.017
Abstract: HIGHLIGHTSDevelopment of a sensitive and selective ultra‐fast liquid chromatography‐tandem mass spectrometry (UFLC–MS/MS) method.Application of UFLC–MS/MS for the determination of RA, sal D, LA and sal B in SAFI in rat plasma.The first pharmacokinetic study of… read more here.
Keywords: rat plasma; salvianolic acid; acid injection; acid ... See more keywords
Determination of AZD3759 in rat plasma and brain tissue by LC–MS/MS and its application in pharmacokinetic and brain distribution studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.03.056
Abstract: &NA; A simple and sensitive high performance liquid chromatography with tandem mass spectrometry (LC–MS/MS) method for determination of AZD3759, a novel epidermal growth factor receptor tyrosine kinase inhibitor, in rat plasma and brain homogenate was… read more here.
Keywords: rat plasma; plasma brain; pharmacokinetic brain; azd3759 rat ... See more keywords
Quantification of cyclocreatine in mouse and rat plasma using hydrophilic‐interaction ultra‐performance liquid chromatography‐tandem mass spectrometry
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.07.049
Abstract: HighlightsRapid, selective, accurate and reproducible HILIC UPLC–MS/MS method to quantify cyclocreatine was developed.Method provided good retention of cyclocreatine with no interference from mouse and rat plasma.The pharmacokinetic parameters of cyclocreatine after oral administration are reported.… read more here.
Keywords: cyclocreatine; rat plasma; plasma; mouse rat ... See more keywords
Bioanalysis of free and liposomal Amphotericin B in rat plasma using solid phase extraction and protein precipitation followed by LC‐MS/MS
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.06.014
Abstract: HIGHLIGHTSFree and liposomal Amphotericin B were effectively separated in rat plasma by solid phase extraction without liposomal breakdown.Liposomal Amphotericin B was quantified by calculating the difference between total and free Amphotericin B.The method was successfully… read more here.
Keywords: rat plasma; amphotericin; phase extraction; liposomal amphotericin ... See more keywords
Determination of tyrosine kinase inhibitor afatinib in rat plasma using LC–MS/MS and its application to in vivo pharmacokinetic studies of afatinib liposomes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.10.043
Abstract: HighlightsA sensitive and rapid LC–MS/MS method for afatinib, with afatinib dimaleate as a standard.Discussed the stability of afatinib in blood in vitro.Development and pharmacokinetic studies for afatinib liposomes. Abstract A sensitive quantitative liquid chromatography‐tandem mass… read more here.
Keywords: rat plasma; plasma; pharmacokinetic studies; afatinib liposomes ... See more keywords
Determination and pharmacokinetic study of echinatin by UPLC‐MS/MS in rat plasma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2019.02.023
Abstract: HighlightsA UPLC‐MS/MS method for determination of echinatin (ECH) was developed and applied.The pharmacokinetic study demonstrated fast absorption and extensive distribution of ECH.Poor oral bioavailability (˜6.81%) of ECH was demonstrated. ABSTRACT Echinatin, one of the bioactive… read more here.
Keywords: rat plasma; study echinatin; pharmacokinetic study; study ... See more keywords