mTORC1 activation contributes to autophagy inhibition via its recruitment to lysosomes and consequent lysosomal dysfunction in cadmium-exposed rat proximal tubular cells.
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DOI: 10.1016/j.jinorgbio.2020.111231
Abstract: Autophagy dysregulation is implicated in cadmium (Cd)-induced nephrotoxicity. The mammalian target of rapamycin complex 1 (mTORC1) is a negative regulator of autophagy, but its role in Cd-induced autophagy inhibition and possible regulatory mechanisms remains poorly… read more here.
Keywords: rat proximal; autophagy inhibition; inhibition; mtorc1 activation ... See more keywords