Human and rat renal proximal tubule in vitro models for ADME applications
Sign Up to like & getrecommendations! Published in 2025 at "Archives of Toxicology"
DOI: 10.1007/s00204-025-03987-4
Abstract: The kidney is a major organ dictating excretion rates of chemicals and their metabolites from the body and thus renal clearance is frequently a major component of pharmaco-(toxico)-kinetic profiles. Within the nephron, the proximal tubule… read more here.
Keywords: rat renal; culture; human rat; tubule ... See more keywords
Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling
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DOI: 10.1038/srep43790
Abstract: Rhubarb and its bioactive component rhein are frequently used for the treatment of chronic kidney diseases (CKD) in eastern Asia countries. However, the potential therapeutic mechanism remains unclear. Autophagy plays an important role in CKD.… read more here.
Keywords: mtor signaling; tubular cells; rat renal; renal fibrosis ... See more keywords
REG1A-mediated the progression of early diabetic nephropathy through regulating autophagy and fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Critical Reviews in Eukaryotic Gene Expression"
DOI: 10.1615/critreveukaryotgeneexpr.2025061365
Abstract: Autophagy deficiency is a clinical feature of early diabetic nephropathy (EDN). This study aimed to investigate the role of REG1A in EDN. Rat renal proximal tubular epithelial cells were exposed to high glucose (HG) to… read more here.
Keywords: renal proximal; rat renal; reg1a; proximal tubular ... See more keywords