Intracellular Delivery of Anti-Kirsten Rat Sarcoma Antibodies Mediated by Polymeric Micelles Exerts Strong In Vitro and In Vivo Anti-Tumorigenic Activity in Kirsten Rat Sarcoma-Mutated Cancers.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c19897
Abstract: The Kirsten rat sarcoma viral oncogene (KRAS) is one of the most well-known proto-oncogenes, frequently mutated in pancreatic and colorectal cancers, among others. We hypothesized that the intracellular delivery of anti-KRAS antibodies (KRAS-Ab) with biodegradable… read more here.
Keywords: kirsten rat; intracellular delivery; delivery anti; rat sarcoma ... See more keywords
Role of rat sarcoma virus mutations in cancer and potential target for cancer therapy
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DOI: 10.2144/fsoa-2019-0045
Abstract: The prevalence of oncogenic rat sarcoma virus (RAS) mutations has made RAS a popular target for cancer therapies. Significant discoveries have been reported regarding cancer molecular biology following the study of RAS mutations. These discoveries… read more here.
Keywords: sarcoma virus; target cancer; cancer; rat sarcoma ... See more keywords
Computational Screening and Analysis of Lung Cancer Related Non-Synonymous Single Nucleotide Polymorphisms on the Human Kirsten Rat Sarcoma Gene
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DOI: 10.3390/molecules24101951
Abstract: The human KRAS (Kirsten rat sarcoma) is an oncogene, involved in the regulation of cell growth and division. The mutations in the KRAS gene have the potential to cause normal cells to become cancerous in… read more here.
Keywords: synonymous single; rat sarcoma; single nucleotide; kirsten rat ... See more keywords