Inhibition of Histone Deacetylase 1 Prevents the Decrease in Titin (Connectin) Content and Development of Atrophy in Rat m. soleus after 3-Day Hindlimb Unloading.
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-020-04907-5
Abstract: We studied the effect of histone deacetylase 1 (HDAC1) inhibition on titin content and expression of TTN gene in rat m. soleus after 3-day gravitational unloading. Male Wistar rats weighing 210±10 g were randomly divided… read more here.
Keywords: titin; day hindlimb; inhibition; day ... See more keywords
Temporal changes in the markers of ribosome biogenesis in rat soleus muscle under simulated microgravity
Sign Up to like & getrecommendations! Published in 2021 at "Acta Astronautica"
DOI: 10.1016/j.actaastro.2021.05.036
Abstract: Abstract Skeletal muscle inactivity due to real or simulated microgravity results in a significant atrophy of muscle fibers. One of the key causes of disuse atrophy is a decrease in the rate of muscle protein… read more here.
Keywords: muscle; temporal changes; ribosome biogenesis; simulated microgravity ... See more keywords
Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles
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DOI: 10.1371/journal.pone.0264171
Abstract: We investigated whether time-of-day dependent changes in the rat soleus (SOL) muscle size, after eccentric exercises, operate via the mechanistic target of rapamycin (mTOR) signaling pathway. For our first experiment, we assigned 9-week-old male Wistar… read more here.
Keywords: light phase; sol muscle; muscle; rat soleus ... See more keywords
The Role of Glycogen Synthase Kinase-3 in the Regulation of Ribosome Biogenesis in Rat Soleus Muscle under Disuse Conditions
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DOI: 10.3390/ijms23052751
Abstract: It is well-established that prolonged exposure to real or simulated microgravity/disuse conditions results in a significant reduction in the rate of muscle protein synthesis (PS) and loss of muscle mass. Muscle protein synthesis is largely… read more here.
Keywords: ribosome biogenesis; soleus muscle; muscle; rat soleus ... See more keywords