Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues.
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DOI: 10.1021/acs.analchem.6b04158
Abstract: Antibodies are an important class of drugs, comprising more than half of all new FDA approvals. Therapeutic antibodies must be chemically stable both in storage and in vivo, following administration to patients. Deamidation is a… read more here.
Keywords: rate adjacent; hydrogen exchange; rate; deamidation ... See more keywords