Acute epileptiform activity induced by gabazine involves proteasomal rather than lysosomal degradation of KCa2.2 channels
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DOI: 10.1016/j.nbd.2018.01.005
Abstract: Voltage-independent, Ca2+-activated K+ channels (KCa2.2, previously named SK2) are typically activated during a train of action potentials, and hence, are powerful regulators of cellular excitability by generating an afterhyperpolarizing potential (AHP) following prolonged excitation. In… read more here.
Keywords: protein; degradation; kca2; rather lysosomal ... See more keywords