Non‐Oxidized Bare Metal Nanoparticles in Air: A Rational Approach for Large‐Scale Synthesis via Wet Chemical Process
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201756
Abstract: Metal nanoparticles (MeNPs) have been used in various industrial applications, owing to their unique physical and chemical properties different from the bulk counterparts. However, the natural oxidation of MeNPs is an imminent hindrance to their… read more here.
Keywords: rational approach; non oxidized; bare; metal nanoparticles ... See more keywords
Rational approach to improve ansamitocin P‐3 production by integrating pathway engineering and substrate feeding in Actinosynnema pretiosum
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26775
Abstract: Ansamitocin P‐3 (AP‐3) produced by Actinosynnema pretiosum is an important antitumor agent for cancer treatment, but its market supply suffers from a low production titer. The role of AP‐3 unusual glycolate unit supply on its… read more here.
Keywords: production; pathway engineering; actinosynnema pretiosum; substrate feeding ... See more keywords
Arginase Inhibitors: A Rational Approach Over One Century
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DOI: 10.1002/med.21419
Abstract: Arginase (EC 3.5.3.1) is the bimanganese enzyme that converts L‐arginine into ornithine and urea. This enzyme was discovered more than a century ago and early α‐amino acids were identified as weak inhibitors. It was only… read more here.
Keywords: arginase inhibitors; arginase; century; rational approach ... See more keywords
A Rational Approach to Tetra‐Functional Photo‐Switches
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DOI: 10.1002/open.201900029
Abstract: Abstract α,ω‐Bis(1,8‐dichloroanthracen‐10‐yl)alkanes with (CH2)n‐linker units (n=1–4) were synthesized starting from 1,8‐dichloroanthracen‐10(9H)‐one. This was transformed into anthracenes with allyl, bromomethyl and propargyl substituents in position 10; these were converted in various C−C‐bond formation reactions (plus hydrogenation),… read more here.
Keywords: photo; tetra functional; functional photo; photo switches ... See more keywords
A rational approach to the use of sophisticated genetic analyses of pediatric stone disease.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2017.08.023
Abstract: Kidney stone disease in the childhood years has a genetic underpinning in some. The relationships between clinical phenotype, medical evaluation, and genetic etiologies were investigated using whole-exome sequencing by the Hildebrandt laboratory. At this time,… read more here.
Keywords: approach use; use sophisticated; disease; stone disease ... See more keywords
Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies
Sign Up to like & getrecommendations! Published in 2018 at "ACS Catalysis"
DOI: 10.1021/acscatal.7b03714
Abstract: Biocatalysts utilize allosteric mechanisms to control selectivity, catalytic activity, and the transport of reaction components. The allosteric control of catalysis has a high potential for the development of drugs and technologies. In particular, it opens… read more here.
Keywords: biocatalysts rational; networks biocatalysts; decoding allosteric; allosteric networks ... See more keywords
Rational approach to guest confinement inside MOF cavities for low-temperature catalysis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08972-x
Abstract: Geometric or electronic confinement of guests inside nanoporous hosts promises to deliver unusual catalytic or opto-electronic functionality from existing materials but is challenging to obtain particularly using metastable hosts, such as metal–organic frameworks (MOFs). Reagents… read more here.
Keywords: confinement; approach guest; rational approach; confinement inside ... See more keywords
A Rational Approach to Drug Repositioning in β-thalassemia: Induction of Fetal Hemoglobin by Established Drugs
Sign Up to like & getrecommendations! Published in 2022 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.17845.3
Abstract: Drug repositioning and the relevance of orphan drug designation for β-thalassemia is reviewed. Drug repositioning and similar terms ('drug repurposing', 'drug reprofiling', 'drug redirecting', ‘drug rescue’, ‘drug re-tasking’ and/or 'drug rediscovery') have gained great attention,… read more here.
Keywords: rational approach; approach drug; drug repositioning; repositioning thalassemia ... See more keywords
What’s Next after Hypomethylating Agents Failure in Myeloid Neoplasms? A Rational Approach
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15082248
Abstract: Simple Summary The hypomethylating agents (HMA) azacitidine and decitabine are among the standard treatment options for myeloid neoplasms. However, the treatment of patients with myelodysplastic syndromes/neoplasms (MDS) and acute myeloid leukemia (AML) who progress after… read more here.
Keywords: rational approach; aml; hypomethylating agents; myeloid neoplasms ... See more keywords
Rational Approach to Finding Genes Encoding Molecular Biomarkers: Focus on Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13091538
Abstract: Early detection of cancer facilitates treatment and improves patient survival. We hypothesized that molecular biomarkers of cancer could be rationally predicted based on even partial knowledge of transcriptional regulation, functional pathways and gene co-expression networks.… read more here.
Keywords: molecular biomarkers; rational approach; breast cancer; cancer ... See more keywords
Laboratory tests in rheumatology: A rational approach
Sign Up to like & getrecommendations! Published in 2019 at "Cleveland Clinic Journal of Medicine"
DOI: 10.3949/ccjm.86a.18076
Abstract: Laboratory tests are useful in diagnosing rheumatic diseases, but clinicians should be aware of the limitations of these tests. This article uses case vignettes to provide practical and evidence-based guidance on requesting and interpreting selected… read more here.
Keywords: rheumatology rational; tests rheumatology; rheumatology; laboratory tests ... See more keywords