Systems approach to rational combination therapy: PARP inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Society transactions"
DOI: 10.1042/bst20191092
Abstract: Poly (ADP-ribose) polymerase inhibitors (PARPi) have demonstrated activity across a broad spectrum of molecular backgrounds and tumor types, with the greatest activity observed in patients with aberrations in the homologous recombination DNA damage repair pathway.… read more here.
Keywords: systems approach; therapy; combination; adaptive responses ... See more keywords
Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-21-0442
Abstract: Abstract We hypothesize that the study of acute protein perturbation in signal transduction by targeted anticancer drugs can predict drug sensitivity of these agents used as single agents and rational combination therapy. We assayed dynamic… read more here.
Keywords: response; drug; rational combination; combination therapy ... See more keywords
Mapping genetic interactions in cancer: a road to rational combination therapies
Sign Up to like & getrecommendations! Published in 2019 at "Genome Medicine"
DOI: 10.1186/s13073-019-0680-4
Abstract: The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2-mutated… read more here.
Keywords: mapping genetic; combination therapies; rational combination; genetic interactions ... See more keywords
BETing on rational combination therapy in mutant FLT3 acute myeloid leukemia
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DOI: 10.3324/haematol.2020.274753
Abstract: therapy in young mice. J Immunol. 2010;184(11):6014-6024. 19.Abou Dalle I, Paranal R, Zarka J, et al. Impact of luteinizing hormone suppression on hematopoietic recovery after intensive chemotherapy in patients with leukemia. Haematologica. 2021;106(4):1097-1105. 20. Poorvu… read more here.
Keywords: mutant flt3; rational combination; beting rational; therapy ... See more keywords