Rational deuteration of dronedarone attenuates its toxicity in human hepatic HepG2 cells.
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DOI: 10.1093/toxres/tfac017
Abstract: Deuteration is a chemical modification strategy that has recently gained traction in drug development. The replacement of one or more hydrogen atom(s) in a drug molecule with its heavier stable isotope deuterium can enhance its… read more here.
Keywords: deuteration; rational deuteration; deuteration dronedarone; dronedarone ... See more keywords