Rational development of molecularly imprinted nanoparticles for blocking PD-1/PD-L1 axis
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DOI: 10.1039/d2sc03412c
Abstract: Blocking the PD-1/PD-L1 immune checkpoint has emerged as a promising strategy in cancer immunotherapy, in which monoclonal antibodies are predominately used as inhibitors. Despite their remarkable success, monoclonal antibody-based therapeutics suffer from drawbacks due to… read more here.
Keywords: blocking axis; development molecularly; molecularly imprinted; rational development ... See more keywords
Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment
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DOI: 10.1186/s12885-018-4712-z
Abstract: BackgroundThe irinotecan-induced phosphokinome changes in colorectal cancer (CRC) cells were used to guide the selection of targeted agents to be tested in combination with irinotecan.MethodsPhosphokinome profiling with peptide arrays of tumour samples from nude mice… read more here.
Keywords: combination; targeted agents; rational development; treatment ... See more keywords