Rational development of fingolimod nano-embedded microparticles as nose-to-brain neuroprotective therapy for ischemic stroke
Sign Up to like & getrecommendations! Published in 2024 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-024-01721-8
Abstract: Ischemic stroke is one of the major diseases causing varying degrees of dysfunction and disability worldwide. The current management of ischemic stroke poses significant challenges due to short therapeutic windows and limited efficacy, highlighting the… read more here.
Keywords: brain; ischemic stroke; nano embedded; rational development ... See more keywords
Rational development of molecularly imprinted nanoparticles for blocking PD-1/PD-L1 axis
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DOI: 10.1039/d2sc03412c
Abstract: Blocking the PD-1/PD-L1 immune checkpoint has emerged as a promising strategy in cancer immunotherapy, in which monoclonal antibodies are predominately used as inhibitors. Despite their remarkable success, monoclonal antibody-based therapeutics suffer from drawbacks due to… read more here.
Keywords: blocking axis; development molecularly; molecularly imprinted; rational development ... See more keywords
Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment
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DOI: 10.1186/s12885-018-4712-z
Abstract: BackgroundThe irinotecan-induced phosphokinome changes in colorectal cancer (CRC) cells were used to guide the selection of targeted agents to be tested in combination with irinotecan.MethodsPhosphokinome profiling with peptide arrays of tumour samples from nude mice… read more here.
Keywords: combination; targeted agents; rational development; treatment ... See more keywords