Mechanism-Based Rational Discovery and In Vitro Evaluation of Novel Microtubule Stabilizing Agents with Non-Taxol-Competitive Activity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b01133
Abstract: Microtubules (MT) are cytoskeletal polymers of αβ-tubulin dimers that play a critical role in many cellular functions. Diverse antimitotic drugs bind to MT and disrupt their dynamics acting as MT stabilizing or destabilizing agents. The… read more here.
Keywords: rational discovery; based rational; discovery vitro; discovery ... See more keywords
Rational discovery of antimetastatic agents targeting the intrinsically disordered region of MBD2
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav9810
Abstract: The intrinsically disordered region of MBD2 is a promising target for treating cancer metastasis. Although intrinsically disordered protein regions (IDPRs) are commonly engaged in promiscuous protein-protein interactions (PPIs), using them as drug targets is challenging… read more here.
Keywords: rational discovery; mbd2; region mbd2; intrinsically disordered ... See more keywords
Rational Discovery of Antimicrobial Peptides by Means of Artificial Intelligence
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12070708
Abstract: Antibiotic resistance is a worldwide public health problem due to the costs and mortality rates it generates. However, the large pharmaceutical industries have stopped searching for new antibiotics because of their low profitability, given the… read more here.
Keywords: rational discovery; antimicrobial peptides; artificial intelligence; discovery antimicrobial ... See more keywords