Rational drug design of CB2 receptor ligands: from 2012 to 2021
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra05661e
Abstract: Cannabinoid receptors belong to the large family of G-protein-coupled receptors, which can be divided into two receptor types, cannabinoid receptor type-1 (CB1) and cannabinoid receptor type-2 (CB2). Marinol, Cesamet and Sativex are marketed CB1 drugs… read more here.
Keywords: selective cb2; cb2; rational drug; drug design ... See more keywords
Binding site matching in rational drug design: algorithms and applications
Sign Up to like & getrecommendations! Published in 2019 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bby078
Abstract: Interactions between proteins and small molecules are critical for biological functions. These interactions often occur in small cavities within protein structures, known as ligand-binding pockets. Understanding the physicochemical qualities of binding pockets is essential to… read more here.
Keywords: site matching; binding site; drug; rational drug ... See more keywords
gene2drug: a computational tool for pathway-based rational drug repositioning
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx800
Abstract: Motivation Drug repositioning has been proposed as an effective shortcut to drug discovery. The availability of large collections of transcriptional responses to drugs enables computational approaches to drug repositioning directly based on measured molecular effects.… read more here.
Keywords: drug repositioning; drug; gene2drug computational; computational tool ... See more keywords
Tetracyclines, a promise for neuropsychiatric disorders: from adjunctive therapy to the discovery of new targets for rational drug design in psychiatry
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000585
Abstract: Major mental disorders, such as schizophrenia, bipolar disorder, and major depressive disorder, represent the leading cause of disability worldwide. Nevertheless, the current pharmacotherapy has several limitations, and a large portion of patients do not respond… read more here.
Keywords: adjunctive therapy; targets rational; neuropsychiatric disorders; new targets ... See more keywords
Model‐informed drug repurposing: Viral kinetic modelling to prioritize rational drug combinations for COVID‐19
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.14486
Abstract: We hypothesized that viral kinetic modelling could be helpful to prioritize rational drug combinations for COVID‐19. The aim of this research was to use a viral cell cycle model of SARS‐CoV‐2 to explore the potential… read more here.
Keywords: prioritize rational; drug; viral kinetic; rational drug ... See more keywords
Investigation of the relationship between rational drug use and healthy lifestyle behaviours of university students.
Sign Up to like & getrecommendations! Published in 2023 at "Global health promotion"
DOI: 10.1177/17579759221134054
Abstract: AIM The aim of this research is to investigate the relationship between rational drug use and healthy lifestyle behaviours of university students. METHOD This descriptive and cross-sectional study consisted of 1115 students from a university… read more here.
Keywords: university; health; drug use; rational drug ... See more keywords
Knowledge and Behavior in Rational Drug Use Among College Students in Zunyi City
Sign Up to like & getrecommendations! Published in 2022 at "Risk Management and Healthcare Policy"
DOI: 10.2147/rmhp.s347822
Abstract: Objective To investigate the current status of knowledge and behavior about rational drug use in college students in different colleges and universities in a city in southwest China, providing reference for students’ education of rational… read more here.
Keywords: drug; drug use; college students; rational drug ... See more keywords
Rational Drug Repurposing: Focus on Lysosomotropism, Targets in Disease Process, Drug Profile, and Pulmonary Tissue Accumulation in SARS-CoV-2 Infection/COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.584881
Abstract: Institute of Precision Medicine, Medical and Life Sciences Faculty, Furtwangen University, Villingen-Schwenningen, Germany, Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg, Germany, Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany, Department… read more here.
Keywords: medicine; germany; drug repurposing; drug ... See more keywords