Animal models for analysis of hypersensitivity reactions to Shuanghuanglian injection.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.03.014
Abstract: Among a variety of traditional Chinese medicines, Shuanghuanglian injection (SHLI), has the highest incidence of injection-induced immediate hypersensitivity reactions (IHRs). However, the precise mechanisms of SHLI-induced IHRs remain to be understood. In the present study,… read more here.
Keywords: shuanghuanglian injection; hypersensitivity reactions; injection; rats dogs ... See more keywords
Contrast efficacy of novel phase convertible nanodroplets for safe CEUS imaging
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DOI: 10.1038/s41598-024-66163-1
Abstract: Microbubble contrast agents in ultrasound/echocardiography are used to increase the echogenicity of the target tissues, thereby raising the contrast resolution of the resultant image. Recently, the trend has shifted toward the development of phase-convertible nanodroplets… read more here.
Keywords: contrast efficacy; contrast; rats dogs; phase convertible ... See more keywords
Cross-species comparison of the metabolism and excretion of selexipag
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DOI: 10.1080/00498254.2018.1444814
Abstract: Abstract 1. The metabolism of the prostacyclin receptor agonist selexipag (NS-304; ACT-293987) and its active metabolite MRE-269 (ACT-333679) has been investigated in liver microsomes and hepatocytes of rats, dogs, and monkeys. MRE-269 formation is the… read more here.
Keywords: cross species; metabolism; selexipag; rats dogs ... See more keywords
Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor
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DOI: 10.1080/00498254.2020.1821123
Abstract: Abstract This article describes in vivo biotransformation and disposition of erdafitinib following single oral dose of 3H-erdafitinib and 14C-erdafitinib to intact and bile duct-cannulated (BC) rats (4 mg/kg), 3H-erdafitinib to intact dogs (0.25 mg/kg), and 14C-erdafitinib to… read more here.
Keywords: disposition rats; erdafitinib major; metabolism disposition; rats dogs ... See more keywords
Pharmacokinetics and mass balance of vericiguat in rats and dogs and distribution in rats
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DOI: 10.1080/00498254.2022.2082899
Abstract: Abstract Vericiguat is a soluble guanylate cyclase stimulator. The pharmacokinetics, absorption, metabolism, and excretion properties of vericiguat in rats and dogs and the distribution in rats are reported. [14C]-labelled vericiguat was studied in intact and… read more here.
Keywords: vericiguat; administration; dogs distribution; distribution rats ... See more keywords
Bioavailability and Pharmacokinetics of Endoxifen in Female Rats and Dogs: Evidence to Support the Use of Endoxifen to Overcome the Limitations of CYP2D6-Mediated Tamoxifen Metabolism
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DOI: 10.1124/dmd.122.000929
Abstract: Endoxifen (ENDX) is an active metabolite of tamoxifen (TAM), a drug commonly used for the treatment of estrogen receptor–positive breast cancer and metabolized by CYP2D6. Genetic or drug-induced reductions in CYP2D6 activity decrease plasma ENDX… read more here.
Keywords: endx; metabolism; female rats; overcome limitations ... See more keywords
Absorption, Metabolism, and Excretion of Taselisib (GDC-0032), a Potent β-Sparing PI3K Inhibitor in Rats, Dogs, and Humans
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DOI: 10.1124/dmd.122.001096
Abstract: Taselisib (also known as GDC-0032) is a potent and selective phosphoinositide 3-kinase (PI3K) inhibitor that displays greater selectivity for mutant PI3Kα than wild-type PI3Kα. To better understand the absorption, distribution, metabolism, and excretion properties of… read more here.
Keywords: metabolism; taselisib; rats dogs; excretion taselisib ... See more keywords
Therapeutic Effects of Total Secondary Ginsenosides on Chronic Heart Failure in Rats and Dogs: A Comparative Study with Xinbao Pills
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DOI: 10.1177/1934578x251316651
Abstract: Objectives Chronic heart failure (CHF) is a prevalent clinical syndrome with high mortality rate. This study evaluates the therapeutic effects of total secondary ginsenosides (TSG) on CHF in rat and dog models compared to Xinbao… read more here.
Keywords: treatment; chronic heart; heart failure; rats dogs ... See more keywords
A novel oral formulation of the melanocortin-1 receptor agonist PL8177 resolves inflammation in preclinical studies of inflammatory bowel disease and is gut restricted in rats, dogs, and humans
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1083333
Abstract: Introduction PL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R). PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated rat ulcerative colitis model. To facilitate oral delivery, a novel,… read more here.
Keywords: pl8177; formulation; rats dogs; melanocortin receptor ... See more keywords
Preclinical studies of NOS inhibitor T1059 vasopressor activity on the models of acute hemorrhagic shock in rats and dogs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.995272
Abstract: The development of new effective and safe vasopressors is one of the ways to increase the effectiveness of the treatment of hypotensive disorders, the severe forms of which remain a common cause of death in… read more here.
Keywords: vasopressor activity; rats dogs; inhibitor; t1059 ... See more keywords
Systematic studies on the kinetic process of 20(S)-protopanaxadiol in rats and dogs: absorption, distribution, metabolism and excretion
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DOI: 10.3389/fphar.2024.1430780
Abstract: Background and Objective Ginseng has been regarded as a precious medicinal herb with miraculous effects in Eastern culture. The primary chemical constituents of ginseng are saponins, and the physiological activities of ginsenosides determine their edible… read more here.
Keywords: rats dogs; metabolism; excretion; absorption distribution ... See more keywords