Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration
Sign Up to like & getrecommendations! Published in 2023 at "Xenobiotica"
DOI: 10.1080/00498254.2023.2179952
Abstract: Abstract The metabolism and pharmacokinetics of fasiglifam (TAK-875, 2-[(3S)-6-[[3-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid), a selective free fatty acid receptor 1 (FFAR1)/GPR40 agonist, were studied following intravenous (5 mg/kg) and oral administration (10 and 50 mg/kg) to male and female Sprague… read more here.
Keywords: female rats; rats following; following oral; tak 875 ... See more keywords
Treadmill workouts alleviate neuropathic allodynia and scratching behavior in rats following thoracotomy
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2021.2024719
Abstract: ABSTRACT Background The aim of the experiment was to investigate the effects of treadmill exercise on postthoracotomy pain and the expression of spinal pro-inflammatory and anti-inflammatory cytokines. Methods Animals were randomly distributed into four groups:… read more here.
Keywords: rats following; thoracotomy; treadmill; allodynia ... See more keywords
Peripheral axonopathy in sciatic nerve of adult Wistar rats following exposure to vanadium
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Peripheral Nervous System"
DOI: 10.1111/jns.12294
Abstract: Depletion of myelin and neurobehavioural deficits are indications that vanadium crosses the blood‐brain barrier and such neurotoxic effects of vanadium on the brain of Wistar rats have been elucidated. The effect however on the peripheral… read more here.
Keywords: wistar rats; following exposure; rats following; exposure vanadium ... See more keywords