Improved physiologically based pharmacokinetic model for oral exposures to chromium in mice, rats, and humans to address temporal variation and sensitive populations
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.03.023
Abstract: ABSTRACT A physiologically based pharmacokinetic (PBPK) model for hexavalent chromium [Cr(VI)] in mice, rats, and humans developed previously (Kirman et al., 2012, 2013), was updated to reflect an improved understanding of the toxicokinetics of the… read more here.
Keywords: rats humans; based pharmacokinetic; mice rats; physiologically based ... See more keywords
Evaluation of 10-Nitro Oleic Acid Bio-Elimination in Rats and Humans
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep39900
Abstract: Nitrated fatty acids are endogenously present in human and animal tissues, as well as in plant-derived oils. In particular, 10-nitro oleic acid (10-NO2-OA) potently induces Nrf2-dependent antioxidant gene expression and inhibits TLR4/NF-κB signaling, thus promoting… read more here.
Keywords: rats humans; nitro oleic; oleic acid; bio elimination ... See more keywords
Talc Inhalation in Rats and Humans
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Occupational and Environmental Medicine"
DOI: 10.1097/jom.0000000000002702
Abstract: The paper reviews animal inhalation and human epidemiological studies with talc. The human studies show that talc can induce COPD and lung fibrosis in workers exposed to high levels to talcum powder. No evidence for… read more here.
Keywords: talc inhalation; inhalation rats; toxicity; rats humans ... See more keywords
Effects of Persimmon Fruit Polyphenols on Postprandial Plasma Glucose Elevation in Rats and Humans.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of nutritional science and vitaminology"
DOI: 10.3177/jnsv.68.331
Abstract: Persimmon is a fruit rich in polyphenols (proanthocyanidins or condensed tannins). Using rats and humans, the effects of Kaki-tannin (Nara-type), persimmon polyphenols prepared using a new method, on postprandial plasma glucose levels were investigated in… read more here.
Keywords: plasma glucose; tannin nara; persimmon fruit; nara type ... See more keywords
OAT3 Participates in Drug–Drug Interaction between Bentysrepinine and Entecavir through Interactions with M8—A Metabolite of Bentysrepinine—In Rats and Humans In Vitro
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041995
Abstract: Bentysrepinine (Y101) is a novel phenylalanine dipeptide for the treatment of hepatitis B virus. Renal excretion played an important role in the elimination of Y101 and its metabolites, M8 and M9, in healthy Chinese subjects,… read more here.
Keywords: y101 entecavir; drug drug; y101; rats humans ... See more keywords
Scaling Pharmacodynamics from Rats to Humans to Support Erythropoietin and Romiplostim Combination Therapy to Treat Erythropoietin-Resistant Anemia
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020344
Abstract: Recombinant human erythropoietin (rHuEPO) is one of the most effective drugs for the treatment of anemia in patients with chronic kidney disease. However, EPO-resistance is an important contributor to the increased risk of adverse effects.… read more here.
Keywords: combination therapy; romiplostim; combination; erythropoietin ... See more keywords