Application of Physiologically Based Pharmacokinetic Modeling to Predict the Effects of FcRn Inhibitors in Mice, Rats, and Monkeys.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.10.065
Abstract: There is a growing interest in developing inhibitors of the neonatal Fc-receptor, FcRn, for use in the treatment for humoral autoimmune conditions. We have developed a new physiologically based pharmacokinetic model that is capable of… read more here.
Keywords: based pharmacokinetic; mice rats; anti fcrn; physiologically based ... See more keywords
Pharmacokinetics and metabolism of mirogabalin, a novel α2δ ligand, in rats and monkeys
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2049396
Abstract: Abstract The purpose of this study was to investigate the pharmacokinetic behaviour of mirogabalin in rats and monkeys. Pharmacokinetic parameters of mirogabalin after its oral and intravenous administration were determined. Distribution study, mass balance study,… read more here.
Keywords: rats monkeys; mirogabalin; metabolism mirogabalin; oral administration ... See more keywords