Phosphine Catalyzed Enantioselective Cascade Reaction Initiated by Intermolecular Cross Rauhut‐Currier Reaction of Electron‐Deficient ortho‐Formyl Styrenes
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DOI: 10.1002/cctc.202000910
Abstract: The Rauhut‐Currier reaction generally employs α,β‐unsaturated carbonyl compounds and nitroalkenes as the substrates. Here we develop an enantioselective formal [4+2] annulation reaction, which is initiated by an intermolecular cross Rauhut‐Currier reaction between electron‐deficient ortho‐formyl‐styrenes and… read more here.
Keywords: initiated intermolecular; rauhut currier; reaction; reaction initiated ... See more keywords
Recent Developments in Intermolecular Cross-Rauhut-Currier Reactions.
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DOI: 10.1002/tcr.202200257
Abstract: Intermolecular cross Rauhut-Currier reactions have gained much importance in recent years. It has proved its importance through procedures involving various catalysts and resulting in complex structures with good regio- as well as stereo- selectivity. This… read more here.
Keywords: currier reactions; cross rauhut; intermolecular cross; rauhut currier ... See more keywords
Solvent-Mediated Enantioselective Rauhut-Currier Cyclization via Iminium and Enamine Activation.
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DOI: 10.1021/acs.orglett.2c04249
Abstract: In this work, we have developed an unconventional and highly enantioselective solvent-promoted Rauhut-Currier cyclization of enal-tethered cyclohexadienone by exploiting the reactivity of a simple Jørgensen-Hayashi catalyst through the merging of iminium and enamine activation. This… read more here.
Keywords: enamine activation; iminium enamine; solvent; rauhut currier ... See more keywords
Enantioselective Synthesis of Functionalized 4-Aryl Hydrocoumarins and 4-Aryl Hydroquinolin-2-ones via Intramolecular Vinylogous Rauhut-Currier Reaction of para-Quinone Methides.
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DOI: 10.1021/acs.orglett.7b01331
Abstract: A novel strategy for the asymmetric construction of functionalized 4-aryl-3,4-dihydrocoumarins and 4-aryl-3,4-dihydroquinolin-2-ones via an intramolecular vinylogous Rauhut-Currier reaction of para-quinone methides (p-QMs) under the bifunctional catalysis of chiral amine-phosphine is described. This intramolecular mode for… read more here.
Keywords: vinylogous rauhut; via intramolecular; ones via; rauhut currier ... See more keywords
Primary Aminothiourea-Catalyzed Enantioselective Synthesis of Rauhut-Currier Adducts of 3-Arylcyclohexenone with a Tethered Enone on the Aryl Moiety at the Ortho-Position.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.7b03959
Abstract: An enantioselective synthesis of Rauhut-Currier (RC) adducts from 3-aryl cyclohexenone with a tethered enone moiety at the ortho-position on the aryl group is accomplished. This method provides a wide range of valuable synthetic building blocks… read more here.
Keywords: tethered enone; moiety ortho; rauhut currier; currier adducts ... See more keywords
Phosphine-Catalyzed Asymmetric Intermolecular Cross-Vinylogous Rauhut–Currier Reactions of Vinyl Ketones with para-Quinone Methides
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DOI: 10.1021/acscatal.7b00030
Abstract: A chiral amide-phosphine bifunctional catalyst was developed and successfully applied to the asymmetric intermolecular cross-vinylogous Rauhut–Currier of alkyl vinyl ketones with para-quinone methides, offering excellent regioselectivity and stereoselectivity (up to >99% enantiomeric excess (ee)). This… read more here.
Keywords: vinyl ketones; vinylogous rauhut; cross vinylogous; rauhut currier ... See more keywords
Multifunctional catalysis: stereoselective construction of α-methylidene-γ-lactams via an amidation/Rauhut-Currier sequence.
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DOI: 10.1039/c7cc02839c
Abstract: Mixing of acryloylchloride, dienone 2, N,N-diisopropylethylamine with chiral organocatalyst 5a, which could simultaneously act as Brønsted and Lewis base catalysts, led to a one-pot amidation/Rauhut-Currier sequence, affording α-methylidene-γ-lactams 4. Catalyst 5a could be recovered and… read more here.
Keywords: amidation rauhut; methylidene lactams; rauhut currier; currier sequence ... See more keywords
An accelerated Rauhut–Currier dimerization enabled the synthesis of (±)-incarvilleatone and anticancer studies
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DOI: 10.3762/bjoc.19.19
Abstract: The total synthesis of racemic incarvilleatone has been achieved by utilizing unexplored accelerated Rauhut–Currier (RC) dimerization. The other key steps of the synthesis are oxa-Michael and aldol reactions in a tandem sequence. Racemic incarvilleatone was… read more here.
Keywords: accelerated rauhut; incarvilleatone; synthesis; rauhut currier ... See more keywords