Total saponin extract, ginsenoside Rb1, and compound K alleviate peripheral and central neuropathic pain through estrogen receptors on rats
Sign Up to like & getrecommendations! Published in 2020 at "Phytotherapy Research"
DOI: 10.1002/ptr.6960
Abstract: In this study, we investigated whether total saponin extract (TSE), ginsenoside Rb1, and Rb1 metabolite compound K, which are isolated from red ginseng, have antinociceptive effects on peripheral and central neuropathic pain (PNP and CNP,… read more here.
Keywords: total saponin; compound; neuropathic pain; rb1 compound ... See more keywords
Ginsenoside Rb1 prevents deoxynivalenol-induced immune injury via alleviating oxidative stress and apoptosis in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112333
Abstract: Deoxynivalenol (DON) is considered to be a grave threat to humans and animals. Ginsenoside Rb1 (Rb1) has been reported for its antioxidant potential and medicinal properties. However, the shielding effects of Rb1 and the precise… read more here.
Keywords: apoptosis; induced immune; mice; immune injury ... See more keywords
Nonionic surfactant vesicles as a novel drug delivery system for increasing the oral bioavailability of Ginsenoside Rb1
Sign Up to like & getrecommendations! Published in 2021 at "Food bioscience"
DOI: 10.1016/j.fbio.2021.101064
Abstract: Abstract In the present study, a novel nonionic surfactant vesicles (NSVs) system consisting of cholesterol, Tween 80 and Span 80 was developed for the delivery of Ginsenoside Rb1 with an improved oral bioavailability. The prepared… read more here.
Keywords: rb1; nonionic surfactant; ginsenoside rb1; oral bioavailability ... See more keywords
Ginsenoside Rb1 ameliorates autophagy via the AMPK/mTOR pathway in renal tubular epithelial cells in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.07.060
Abstract: Although ginsenoside Rb1 (G-Rb1) has exerted an inhibitory effect on renal fibrosis and progression of chronic kidney disease (CKD), its mechanism remains unknown. This study aims to explore the anti-fibrosis effect of G-Rb1 in unilateral… read more here.
Keywords: treatment; ampk mtor; effect; ginsenoside rb1 ... See more keywords
Ginsenoside Rb1 is an immune-stimulatory agent with antiviral activity against enterovirus 71.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113401
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE According to the theory of traditional Chinese medicine, the main pathogenesis of severe hand, foot and mouth disease (HFMD) is that the heat and wet poisons are deeply trapped in the viscera, which… read more here.
Keywords: rb1 immune; antiviral activity; ginsenoside rb1; immune stimulatory ... See more keywords
Ginsenoside Rb1 inhibits monoiodoacetate-induced osteoarthritis in postmenopausal rats through prevention of cartilage degradation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Ginseng Research"
DOI: 10.1016/j.jgr.2020.01.004
Abstract: Background Ginsenoside Rb1 (G-Rb1), one of the major active compounds in Panax ginseng, has already been shown to reduce inflammation in various diseases. Osteoarthritis (OA) has traditionally been considered a degenerative disease with degradation of… read more here.
Keywords: degradation; mia induced; ginsenoside rb1; rb1 ... See more keywords
Ginsenoside Rb1 mitigates oxidative stress and apoptosis induced by methylglyoxal in SH-SY5Y cells via the PI3K/Akt pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2019.101469
Abstract: Diabetic encephalopathy is a severe diabetic complication characterized by cognitive dysfunction and neuropsychiatric disability. Methylglyoxal (MGO), a highly reactive metabolite of hyperglycemia, serves as a major precursor of advanced glycation end products that play key… read more here.
Keywords: mgo; apoptosis; rb1; sy5y cells ... See more keywords
Ginsenoside Rb1 ameliorates Staphylococcus aureus-induced Acute Lung Injury through attenuating NF-κB and MAPK activation.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.05.003
Abstract: Acute lung injury (ALI) is clinically characterized by excessive inflammation leading to acute respiratory distress syndrome (ARDS), having high morbidity and mortality both in human and animals. Ginsenoside Rb1 (Rb1) is a major primary bioactive… read more here.
Keywords: acute lung; rb1; lung injury; aureus induced ... See more keywords
Generation of human embryonic stem cell line with heterozygous RB1 deletion by CRIPSR/Cas9 nickase
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DOI: 10.1016/j.scr.2018.01.021
Abstract: The Retinoblastoma 1 (RB1) tumor suppressor, a member of the Retinoblastoma gene family, functions as a pocket protein for the functional binding of E2F transcription factors. About 1/3 of retinoblastoma patients harbor a germline RB1… read more here.
Keywords: stem cell; rb1; cell line; deletion ... See more keywords
Biallelic and monoallelic deletion of the RB1 promoter in six isogenic clonal H9 hESC lines.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101779
Abstract: Retinoblastoma is a childhood tumor of the retina that is caused mostly by biallelic inactivation of the tumor suppressor gene RB1. To generate a research resource, we abrogated expression of RB1 in H9 hESCs by… read more here.
Keywords: rb1 promoter; biallelic monoallelic; deletion; deletion rb1 ... See more keywords
Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02495-2
Abstract: Inactivation of RB is one of the hallmarks of cancer, however gaps remain in our understanding of how RB-loss changes human cells. Here we show that pRB-depletion results in cellular reprogramming, we quantitatively measured how… read more here.
Keywords: human cells; analysis; cancer; rb1 ... See more keywords