Biallelic and monoallelic deletion of the RB1 promoter in six isogenic clonal H9 hESC lines.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101779
Abstract: Retinoblastoma is a childhood tumor of the retina that is caused mostly by biallelic inactivation of the tumor suppressor gene RB1. To generate a research resource, we abrogated expression of RB1 in H9 hESCs by… read more here.
Keywords: rb1 promoter; biallelic monoallelic; deletion; deletion rb1 ... See more keywords
RB1‑promoter methylation in glioblastoma: A rare event in glioblastoma.
Sign Up to like & getrecommendations! Published in 2023 at "Oncology reports"
DOI: 10.3892/or.2023.8580
Abstract: The retinoblastoma gene (RB1) is a tumor suppressor gene that serves a key role in the development of numerous tumor diseases that can be downregulated by DNA methylation within its promoter region. The present study… read more here.
Keywords: promoter; methylation; glioblastoma; promoter methylation ... See more keywords