Class switching is differentially regulated in RBC alloimmunization and vaccination
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DOI: 10.1111/trf.17301
Abstract: Studies of human patients have shown that most anti‐RBC alloantibodies are IgG1 or IgG3 subclasses, although it is unclear why transfused RBCs preferentially drive these subclasses over others. Though mouse models allow for the mechanistic… read more here.
Keywords: class switching; rbc alloimmunization; switching differentially; vaccination ... See more keywords
Risk of RBC alloimmunization in multiple myeloma patients treated by Daratumumab
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DOI: 10.1111/vox.12864
Abstract: Daratumumab (DARA) is a human monoclonal antibody for the treatment of multiple myeloma (MM). DARA binds to CD38 on RBCs and interferes with detection of RBC alloantibodies. The objective of this study was to evaluate… read more here.
Keywords: multiple myeloma; rbc alloimmunization; risk rbc; patients treated ... See more keywords
FCGR2B B2.4 Haplotype Predicts Increased Risk of Red Blood Cell Alloimmunization in Sickle Cell Disease Patients
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DOI: 10.1182/blood-2018-99-113896
Abstract: Introduction: Red blood cell (RBC) alloimmunization is an important transfusion complication which is very prevalent among patients with sickle cell disease (SCD). Only part of patients is able to develop alloantibodies following antigen-mismatched transfusions, named… read more here.
Keywords: fcgr2b haplotype; alloimmunization; risk; rbc alloimmunization ... See more keywords
Type 1 Interferon Promotes RBC Alloimmunization in a Lupus Mouse Model
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DOI: 10.1182/blood-2019-130903
Abstract: Background: Red blood cell (RBC) alloimmunization can follow exposure to foreign RBC antigens during transfusion therapy and during pregnancy/delivery. Alloantibodies against RBC antigens can cause potentially fatal hemolytic transfusion reactions and hemolytic disease of the… read more here.
Keywords: alloimmunization; pristane; transfusion; rbc alloimmunization ... See more keywords
HLA and HNA Antibodies Are More Prevalent in Multiparous Women with Red Blood Cell Alloimmunization
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DOI: 10.1182/blood.v130.suppl_1.3731.3731
Abstract: Background: Leukocyte antibodies against HLA class I, class II and human neutrophil antigens (HNA) are formed from exposure to these antigens by transfusion, pregnancy or transplant, and may be associated with transfusion-related acute lung injury… read more here.
Keywords: rbc alloimmunization; alloimmunization; hna anti; anti hna ... See more keywords
Reticulocytes in donor blood units enhance red blood cell alloimmunization.
Sign Up to like & getrecommendations! Published in 2023 at "Haematologica"
DOI: 10.3324/haematol.2023.282815
Abstract: Although red blood cell (RBC) transfusions save lives, some patients develop clinically-significant alloantibodies against donor blood group antigens, which then have adverse effects in multiple clinical settings. Few effective measures exist to prevent RBC alloimmunization… read more here.
Keywords: red blood; rbc alloimmunization; blood; blood cell ... See more keywords