Proline-Rich Chaperones Are Compared Computationally and Experimentally for Their Abilities to Facilitate Recombinant Butyrylcholinesterase Tetramerization in CHO Cells.
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DOI: 10.1002/biot.201700479
Abstract: Human butyrylcholinesterase (BChE), predominantly tetramers with a residence time of days, offers the potential to scavenge organophosphorus pesticides and chemical warfare agents. Efficient assembly of human BChE into tetramers requires an association with proline-rich peptide… read more here.
Keywords: rich chaperones; cho cells; rbche; proline rich ... See more keywords
Purification and site-specific N-glycosylation analysis of human recombinant butyrylcholinesterase from Nicotiana benthamiana
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DOI: 10.1016/j.bej.2018.11.004
Abstract: Abstract Butyrylcholinesterase (BChE) is a glycosylated serine hydrolase found in human serum that has been shown to protect against various cholinesterase-inhibiting organophosphate nerve agents. The supply of plasma-derived butyrylcholinesterase (hBChE) is constrained by the availability… read more here.
Keywords: purification; specific glycosylation; nicotiana benthamiana; butyrylcholinesterase ... See more keywords