Difference in LET‐based biological doses between IMPT optimization techniques: Robust and PTV‐based optimizations
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.12844
Abstract: Abstract Purpose While a large amount of experimental data suggest that the proton relative biological effectiveness (RBE) varies with both physical and biological parameters, current commercial treatment planning systems (TPS) use the constant RBE instead… read more here.
Keywords: rbe; distance; rbe models; optimization techniques ... See more keywords
Modeling RBE-weighted dose variations in irregularly moving abdominal targets treated with carbon ion beams.
Sign Up to like & getrecommendations! Published in 2020 at "Medical physics"
DOI: 10.1002/mp.14135
Abstract: PURPOSE To model 4-Dimensional (4D) Relative Biological Effectiveness (RBE)-weighted dose variations in abdominal lesions treated with scanned carbon ion beam in case of irregular breathing motion. METHODS The proposed method, referred to as bioWED method,… read more here.
Keywords: motion; rbe; rbe weighted; estimation error ... See more keywords
Novel radiation quality metrics accounting for proton energy spectra for RBE proton models.
Sign Up to like & getrecommendations! Published in 2024 at "Medical physics"
DOI: 10.1002/mp.17236
Abstract: BACKGROUND For proton therapy, a relative biological effectiveness (RBE) of 1.1 is widely applied clinically. However, due to abundant evidence of variable RBE in vitro, and as suggested in studies of patient outcomes, RBE might… read more here.
Keywords: text let; proton; rbe; variable rbe ... See more keywords
Pharmacokinetics of vitamin E, γ-oryzanol, and ferulic acid in healthy humans after the ingestion of a rice bran-enriched porridge prepared with water or with milk
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nutrition"
DOI: 10.1007/s00394-018-1770-6
Abstract: PurposeIn this study, we investigated the absorption and excretion kinetics of antioxidant dietary phytochemicals (vitamin E, γ-oryzanol, and ferulic acid) in healthy humans after the ingestion of an oatmeal porridge supplemented with rice bran extract… read more here.
Keywords: milk; rbe; water; porridge ... See more keywords
Contralateral repeated bout effect after eccentric exercise on muscular activation
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Applied Physiology"
DOI: 10.1007/s00421-018-3933-9
Abstract: PurposeThe purpose of this study was to investigate the contralateral and ipsilateral repeated bout effects of eccentric contractions (ECCs) on muscle fiber activation using transverse relaxation time (T2) of magnetic resonance imaging (MRI).MethodsEleven men (22.3 ± 2.9 years)… read more here.
Keywords: rbe rbe; repeated bout; rbe; muscle ... See more keywords
Rice bran extract attenuates cognitive impairment by enhancing pancreatic β-cell insulin secretion in STZ-induced diabetic rats targeting the PPARγ/PDX1 pathway
Sign Up to like & getrecommendations! Published in 2025 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-025-01639-1
Abstract: Type I diabetes (T1D), also known as juvenile diabetes, is an autoimmune disease that causes gradual destruction of pancreatic cells and leads to intellectual disability, neuropathy, cognitive impairment, and impaired learning ability in children. Despite… read more here.
Keywords: rice bran; insulin secretion; insulin; rbe ... See more keywords
Fixed- versus Variable-RBE Computations for Intensity Modulated Proton Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Advances in Radiation Oncology"
DOI: 10.1016/j.adro.2018.08.020
Abstract: Purpose To evaluate how using models of proton therapy that incorporate variable relative biological effectiveness (RBE) versus the current practice of using a fixed RBE of 1.1 affects dosimetric indices on treatment plans for large… read more here.
Keywords: rbe; variable rbe; intensity modulated; proton therapy ... See more keywords
In Silico Models of DNA Damage and Repair in Proton Treatment Planning: A Proof of Concept
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DOI: 10.1038/s41598-019-56258-5
Abstract: There is strong in vitro cell survival evidence that the relative biological effectiveness (RBE) of protons is variable, with dependence on factors such as linear energy transfer (LET) and dose. This is coupled with the… read more here.
Keywords: dna damage; rbe; damage repair; treatment ... See more keywords
Evaluating very high energy electron RBE from nanodosimetric pBR322 plasmid DNA damage
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82772-6
Abstract: This paper presents the first plasmid DNA irradiations carried out with Very High Energy Electrons (VHEE) over 100–200 MeV at the CLEAR user facility at CERN to determine the Relative Biological Effectiveness (RBE) of VHEE.… read more here.
Keywords: dna damage; rbe; dna; high energy ... See more keywords
Evaluation of specific RBE in different cells of hippocampus under high-dose proton irradiation in rats
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-58831-z
Abstract: The study aimed to determine the specific relative biological effectiveness (RBE) of various cells in the hippocampus following proton irradiation. Sixty Sprague–Dawley rats were randomly allocated to 5 groups receiving 20 or 30 Gy of… read more here.
Keywords: cells hippocampus; proton; different cells; rbe ... See more keywords
Impact of respiratory motion on variable relative biological effectiveness in 4D-dose distributions of proton therapy
Sign Up to like & getrecommendations! Published in 2017 at "Acta Oncologica"
DOI: 10.1080/0284186x.2017.1354131
Abstract: Abstract Background: Organ motion during radiation therapy with scanned protons leads to deviations between the planned and the delivered physical dose. Using a constant relative biological effectiveness (RBE) of 1.1 linearly maps these deviations into… read more here.
Keywords: motion; recalculation; rbe; variable rbe ... See more keywords