The long non‐coding RNA MALAT1 promotes ovarian cancer progression by regulating RBFOX2‐mediated alternative splicing
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22919
Abstract: Ovarian cancer metastasizes via direct seeding, whereby cancer cells shed from the primary site, resist cell death in the peritoneal cavity, then metastasize to peritoneal organs. We sought to identify molecular mechanisms that facilitate ovarian… read more here.
Keywords: long non; malat1; rbfox2; expression ... See more keywords
LncRNA ZFAS1 promotes laryngeal cancer progression through RBFOX2‐mediated MENA alternative splicing
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23695
Abstract: Laryngeal cancer (LC) is the most common aggressive malignancy of the head and neck. LncRNA ZNFX1 antisense RNA 1 (ZFAS1) displays oncogenic properties in head and neck squamous cell carcinoma, but its regulatory role in… read more here.
Keywords: zfas1; rbfox2; laryngeal cancer; cancer progression ... See more keywords
Alternative splicing induces cytoplasmic localization of RBFOX2 protein in calcific tendinopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2019.104264
Abstract: BACKGROUND Calcific tendinopathy (CT) is characterized by deposits of calcium, most commonly found in the shoulder tendons. The exact cause and pathogenesis of CT are not fully understood. This study analyzed the expression pattern of… read more here.
Keywords: protein; rbfox2 protein; rbfox2; calcific ... See more keywords
RBFOX2 is required for establishing RNA regulatory networks essential for heart development
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac055
Abstract: Abstract Human genetic studies identified a strong association between loss of function mutations in RBFOX2 and hypoplastic left heart syndrome (HLHS). There are currently no Rbfox2 mouse models that recapitulate HLHS. Therefore, it is still… read more here.
Keywords: heart development; rbfox2; cell ecm; heart ... See more keywords
RBFOX2-regulated TEAD1 alternative splicing plays a pivotal role in Hippo-YAP signaling
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac509
Abstract: Abstract Alternative pre-mRNA splicing is key to proteome diversity; however, the biological roles of alternative splicing (AS) in signaling pathways remain elusive. Here, we focus on TEA domain transcription factor 1 (TEAD1), a YAP binding… read more here.
Keywords: rbfox2 regulated; tead1; alternative splicing; yap ... See more keywords