LAUSR

RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition.

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2 Published in 2023 at "Cancer research"

DOI: 10.1158/0008-5472.can-22-1549

Abstract: In lung adenocarcinoma (LUAD), loss-of-function mutations in the splicing factor RBM10 frequently co-occur with oncogenic EGFR mutations. A detailed understanding of the functional consequences and therapeutic impact of RBM10 loss in EGFR-mutant LUAD could help… read more here.

Keywords: rbm10 loss; egfr driven; loss; lung ... See more keywords