Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex
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DOI: 10.1038/s41589-019-0411-6
Abstract: The anticancer agent indisulam inhibits cell proliferation by causing degradation of RBM39, an essential mRNA splicing factor. Indisulam promotes an interaction between RBM39 and the DCAF15 E3 ligase substrate receptor, leading to RBM39 ubiquitination and… read more here.
Keywords: degradation; indisulam; rbm39; dcaf15 ... See more keywords
Systematic pan‐cancer analysis identifies RBM39 as an immunological and prognostic biomarker
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DOI: 10.1111/jcmm.17517
Abstract: Abstract RNA‐binding Motif Protein39 (RBM39) is identified as a splicing factor and transcription coactivator. Despite mounting evidence that RBM39 plays a critical role in the development of specific malignancies, no systematic pan‐cancer investigation of RBM39… read more here.
Keywords: rbm39 expression; rbm39; pan cancer; expression ... See more keywords
The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation
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DOI: 10.1371/journal.pbio.3003486
Abstract: The persistence of latent HIV-1 reservoirs remains a critical barrier to functional curing AIDS, as current latency-reversing agents (LRAs) exhibit limited clinical efficacy. While RNA modifications like N⁶-methyladenosine (m⁶A) regulate viral replication, their role in… read more here.
Keywords: rbm39; binding protein; rna decay; rna binding ... See more keywords