CRMSS: predicting circRNA-RBP binding sites based on multi-scale characterizing sequence and structure features
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac530
Abstract: Circular RNAs (circRNAs) are reverse-spliced and covalently closed RNAs. Their interactions with RNA-binding proteins (RBPs) have multiple effects on the progress of many diseases. Some computational methods are proposed to identify RBP binding sites on… read more here.
Keywords: multi scale; sequence; circrna rbp; rbp binding ... See more keywords
MotifMap‐RNA: a genome‐wide map of RBP binding sites
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx087
Abstract: Motivation: RNA plays a critical role in gene expression and its regulation. RNA binding proteins (RBPs), in turn, are important regulators of RNA. Thanks to the availability of large scale data for RBP binding motifs… read more here.
Keywords: motifmap rna; binding sites; rbp binding; uci edu ... See more keywords
CRBSP:Prediction of CircRNA-RBP binding sites based on multimodal intermediate fusion.
Sign Up to like & getrecommendations! Published in 2023 at "IEEE/ACM transactions on computational biology and bioinformatics"
DOI: 10.1109/tcbb.2023.3272400
Abstract: Circular RNA (CircRNA) is widely expressed and has physiological and pathological significance, regulating post-transcriptional processes via its protein-binding activity. However, whereas much work has been done on linear RNA and RNA binding protein (RBP), little… read more here.
Keywords: circrna; fusion; crbsp; rbp binding ... See more keywords
Deep neural networks for inferring binding sites of RNA-binding proteins by using distributed representations of RNA primary sequence and secondary structure
Sign Up to like & getrecommendations! Published in 2020 at "BMC Genomics"
DOI: 10.1186/s12864-020-07239-w
Abstract: Background RNA binding proteins (RBPs) play a vital role in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport, and modulation of mRNA translation and decay. The identification of RBP binding sites is… read more here.
Keywords: distributed representations; deep neural; binding proteins; rna binding ... See more keywords
A proposed molecular mechanism for pathogenesis of severe RNA-viral pulmonary infections.
Sign Up to like & getrecommendations! Published in 2020 at "F1000Research"
DOI: 10.12688/f1000research.25390.1
Abstract: Background: Certain riboviruses can cause severe pulmonary complications leading to death in some infected patients. We propose that DNA damage induced-apoptosis accelerates viral release, triggered by depletion of host RNA binding proteins (RBPs) from nuclear… read more here.
Keywords: binding sites; rbp binding; rna viral; dna ... See more keywords