The ANK repeats of Notch-4/Int3 activate NF-κB canonical pathway in the absence of Rbpj and causes mammary tumorigenesis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13989-7
Abstract: Transgenic mice expressing the Notch-4 intracellular domain (designated Int3) in the mammary gland have two phenotypes exhibited with 100% penetrance: arrest of mammary alveolar/lobular development and mammary tumorigenesis. Notch-4 signaling is mediated primarily through the… read more here.
Keywords: rbpj; wap int3; ank repeats; mammary tumorigenesis ... See more keywords
Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28420-y
Abstract: In vertebrate retinal progenitor cells, the proneural factor Atoh7 exhibits a dynamic tissue and cellular expression pattern. Although the resulting Atoh7 retinal lineage contains all seven major cell types, only retinal ganglion cells require Atoh7… read more here.
Keywords: regulation atoh7; transcription; atoh7 transcription; rbpj ... See more keywords
The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1137
Abstract: The highly conserved Notch pathway transmits signals between neighboring cells to elicit distinct downstream transcriptional programs. In given contexts, Notch is a major regulator of cell fate specification, proliferation, and apoptosis, such that aberrant Notch… read more here.
Keywords: rbpj; structure; transcription; l3mbtl3 ... See more keywords
FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq4831
Abstract: Dysregulation of the Notch–RBPJ (recombination signal-binding protein of immunoglobulin kappa J region) signaling pathway has been found associated with various human diseases including cancers; however, precisely how this key signaling pathway is fine-tuned via its… read more here.
Keywords: notch signaling; rbpj; fbxo42; chromatin relaxation ... See more keywords
Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation
Sign Up to like & getrecommendations! Published in 2023 at "Stroke"
DOI: 10.1161/strokeaha.122.041853
Abstract: Background: Brain arteriovenous malformations (bAVM) are characterized by enlarged blood vessels, which direct blood through arteriovenous shunts, bypassing the artery-capillary-vein network and disrupting blood flow. Clinically, bAVM treatments are invasive and not routinely applicable. There… read more here.
Keywords: cell; brain ecs; rbpj; apelin ... See more keywords
RTA and LANA Competitively Regulate let-7a/RBPJ Signal to Control KSHV Replication
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.804215
Abstract: The recombination signal binding protein for immunoglobulin kappa J region (RBPJ) has a dual effect on Kaposi’s sarcoma-associated herpesvirus (KSHV) replication. RBPJ interaction with replication and transcription activator (RTA) is essential for lytic replication, while… read more here.
Keywords: rta; expression; rbpj; let ... See more keywords
Pathological pericyte expansion and impaired endothelial cell-pericyte communication in endothelial Rbpj deficient brain arteriovenous malformation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Human Neuroscience"
DOI: 10.3389/fnhum.2022.974033
Abstract: Pericytes, like vascular smooth muscle cells, are perivascular cells closely associated with blood vessels throughout the body. Pericytes are necessary for vascular development and homeostasis, with particularly critical roles in the brain, where they are… read more here.
Keywords: rbpj; communication; brain; pericyte ... See more keywords
Identification of Potential RBPJ-Specific Inhibitors for Blocking Notch Signaling in Breast Cancer Using a Drug Repurposing Strategy
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DOI: 10.3390/ph15050556
Abstract: Notch signaling is a key parameter in regulating cell fate during tissue homeostasis, and an aberrant Notch pathway can result in mammary gland carcinoma and has been associated with poor breast cancer diagnosis. Although inhibiting… read more here.
Keywords: breast cancer; notch signaling; rbpj;
Interaction between BEND5 and RBPJ suppresses breast cancer growth and metastasis via inhibiting Notch signaling
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.70866
Abstract: High frequent metastasis is the major cause of breast cancer (BC) mortality among women. However, the molecular mechanisms underlying BC metastasis remain largely unknown. Here, we identified six hub BC metastasis driver genes (BEND5, HSD11B1,… read more here.
Keywords: metastasis; notch signaling; rbpj; bend5 ... See more keywords