mRNA translational specialization by RBPMS presets the competence for cardiac commitment in hESCs
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade1792
Abstract: The blueprints of developing organs are preset at the early stages of embryogenesis. Transcriptional and epigenetic mechanisms are proposed to preset developmental trajectories. However, we reveal that the competence for the future cardiac fate of… read more here.
Keywords: cardiac commitment; mrna translation; mrna translational; rbpms ... See more keywords
RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental cell"
DOI: 10.2139/ssrn.3965532
Abstract: Noncompaction cardiomyopathy is a common congenital cardiac disorder associated with abnormal ventricular cardiomyocyte trabeculation and impaired pump function. The genetic basis and underlying mechanisms of this disorder remain elusive. We show that the genetic deletion… read more here.
Keywords: binding protein; rna binding; cardiomyocyte binucleation; rna ... See more keywords