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   Articles with "rcan1" as a keyword



Upregulation of RCAN1.4 by HIF1α alleviates OGD‐induced inflammatory response in astrocytes

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recommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.51624

Abstract: Ischemic stroke is a leading cause of human mortality and long‐term disability worldwide. As one of the main forms of regulator of calcineurin 1 (RCAN1), the contribution of RCAN1.4 in diverse biological and pathological conditions… read more here.

Keywords: hif1 alleviates; rcan1; rcan1 hif1; rcan1 ischemic ... See more keywords

Decreased activity of RCAN1.4 is a potential risk factor for congenital heart disease in a Han Chinese population

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recommendations! Published in 2018 at "Protein & Cell"

DOI: 10.1007/s13238-018-0525-8

Abstract: Congenital heart disease (CHD) is a major birth defect worldwide. However, the aetiology of CHD remains unclear and the detailed molecular mechanisms underlying CHD pathogenesis have not been fully understood. The human regulator of calcineurin… read more here.

Keywords: rcan1; chd; congenital heart; mouse ... See more keywords

Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4.

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recommendations! Published in 2020 at "Cancer letters"

DOI: 10.1016/j.canlet.2020.01.023

Abstract: Tumor-derived exosomes (TEXs) contain enriched miRNAs that act as novel non-invasive biomarkers for cancer diagnosis and play a role in cancer progression. We investigated the exosomal miRNAs that affect cancer progression in non-small cell lung… read more here.

Keywords: rcan1; angiogenesis; metastasis; mir 619 ... See more keywords

Alpha-2 macroglobulin in Alzheimer’s disease: a marker of neuronal injury through the RCAN1 pathway

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recommendations! Published in 2017 at "Molecular Psychiatry"

DOI: 10.1038/mp.2016.206

Abstract: Preclinical changes that precede the onset of symptoms and eventual diagnosis of Alzheimer’s disease (AD) are a target for potential preventive interventions. A large body of evidence suggests that inflammation is closely associated with AD… read more here.

Keywords: rcan1; alzheimer disease; disease; neuronal injury ... See more keywords

NF-κB signaling pathway inhibition suppresses hippocampal neuronal apoptosis and cognitive impairment via RCAN1 in neonatal rats with hypoxic-ischemic brain damage

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recommendations! Published in 2019 at "Cell Cycle"

DOI: 10.1080/15384101.2019.1608128

Abstract: ABSTRACT NF-κB is a core transcription factor, the activation of which can lead to hypoxic-ischemic brain damage (HIBD), while RCAN1 plays a protective role in HIBD. However, the relationship between NF-κB and RCAN1 in HIBD… read more here.

Keywords: rcan1; hibd; neuronal apoptosis; signaling pathway ... See more keywords

#446 Trametinib ameliorated adriamycin-induced podocyte injury through METTL3 modified m6A RCAN1 mRNA methylation

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recommendations! Published in 2025 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaf116.0206

Abstract: The extracellular signal-regulated kinase-1/2 (ERK1/2) signalling pathway enhances the expression of N6-adenosine-methyltransferase-like 3 (METTL3). Trametinib, a commonly utilized ERK1/2 inhibitor, has been shown to protect against acute and chronic kidney damage. However, its epigenetic mechanisms… read more here.

Keywords: m6a; mettl3; podocyte injury; rcan1 ... See more keywords

Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network

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recommendations! Published in 2018 at "Circulation Research"

DOI: 10.1161/circresaha.117.311522

Abstract: Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the Down syndrome critical region. The… read more here.

Keywords: rcan1; syndrome critical; mitochondrial network; critical region ... See more keywords
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RCAN1 in cardiovascular diseases: molecular mechanisms and a potential therapeutic target

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recommendations! Published in 2020 at "Molecular Medicine"

DOI: 10.1186/s10020-020-00249-0

Abstract: Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Considerable efforts are needed to elucidate the underlying mechanisms for the prevention and treatment of CVDs. Regulator of calcineurin 1 (RCAN1) is involved in both… read more here.

Keywords: rcan1 cardiovascular; rcan1; cvds; cardiovascular diseases ... See more keywords

Liraglutide alleviates vascular injury in diabetic rabbits with lower limb vascular stenosis through regulation of RCAN1.

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recommendations! Published in 2022 at "European review for medical and pharmacological sciences"

DOI: 10.26355/eurrev_202206_28968

Abstract: OBJECTIVE The aim of the present study is to explore the possible mechanism that may have ameliorative effect of liraglutide (Lira) on diabetic lower extremity vascular stenosis. MATERIALS AND METHODS A diabetic rabbit model of… read more here.

Keywords: vascular injury; lower extremity; rcan1; vascular stenosis ... See more keywords