Abstract 2817: Combining the RCAS/TVA retrovirus system and a conditional oncohistone H3.3K27M allele to investigate radiosensitization strategies in primary mouse models of diffuse midline glioma
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DOI: 10.1158/1538-7445.am2023-2817
Abstract: Diffuse midline gliomas (DMGs) are deadly brain tumors characterized by inactivating TP53 mutations and oncohistone H3.3K27M mutations. One potential strategy to improve outcomes for DMG patients is to inhibit Ataxia-telangiectasia mutated kinase (ATM), an orchestrator… read more here.
Keywords: tva; system; diffuse midline; oncohistone 3k27m ... See more keywords