Pharmacokinetics and Pharmacodynamics of Repository Corticotropin Injection Compared With Synthetic ACTH1-24 Depot and Methylprednisolone in Healthy Subjects.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1020
Abstract: Repository corticotropin injection (RCI; Acthar Gel) is a naturally sourced complex mixture of adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides. This phase 1, single-center, open-label, randomized parallel study directly compared the pharmacokinetics and pharmacodynamics… read more here.
Keywords: repository corticotropin; rci; synthetic acth1; acth1 depot ... See more keywords
Clinical and Economic Evaluation of Repository Corticotropin Injection: A Narrative Literature Review of Treatment Efficacy and Healthcare Resource Utilization for Seven Key Indications
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DOI: 10.1007/s12325-017-0569-9
Abstract: IntroductionRepository corticotropin injection (RCI; H.P. Acthar® Gel; Mallinckrodt Pharmaceuticals Inc., Hampton, NJ) is a highly purified, prolonged-release porcine preparation of adrenocorticotropic hormone (ACTH) analogue that is FDA-approved for treatment of 19 autoimmune and inflammatory disorders.… read more here.
Keywords: narrative literature; rci; corticotropin injection; treatment ... See more keywords
Consequences of Insurance Denials Among U.S. Patients Prescribed Repository Corticotropin Injection for Acute Exacerbations of Multiple Sclerosis
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DOI: 10.1007/s40120-020-00219-y
Abstract: Repository corticotropin injection (RCI; Acthar® Gel) is indicated for the treatment of acute exacerbations of multiple sclerosis (MS) in adults. Despite the well-documented clinical and economic benefits of RCI, many patients are denied use of… read more here.
Keywords: repository corticotropin; acute exacerbations; rci; corticotropin injection ... See more keywords
Treatable causes of adult-onset rapid cognitive impairment
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DOI: 10.1016/j.clineuro.2019.105575
Abstract: OBJECTIVES Acute and subacute cognitive decline, defined collectively as rapid cognitive impairment (RCI), is attributed to diverse disorders and brings great challenges for differential diagnosis. In this study we investigated the RCI patients to determine… read more here.
Keywords: rci patients; rci; cognitive impairment; rapid cognitive ... See more keywords
Logistic versus linear regression-based reliable change index: A simulation study with implications for clinical studies with different sample sizes.
Sign Up to like & getrecommendations! Published in 2022 at "Psychological assessment"
DOI: 10.1037/pas0001138
Abstract: The linear regression-based reliable change index (RCI) is widely used to identify memory impairments through longitudinal assessment. However, the minimum sample size required for estimates to be reliable has never been specified. Using data from… read more here.
Keywords: linear regression; regression based; reliable change; change index ... See more keywords
dTMP-GH Fusion Protein Therapy Improves Survival after Radiation Injury Combined with Skin-Burn Trauma in Mice
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DOI: 10.1667/rr5218.1
Abstract: Exposure to ionizing radiation combined with traumatic tissue injury is an important life-threatening condition found in the civilian populations after nuclear and radiological events. The significance feature of radiation combined injury (RCI) is the severe… read more here.
Keywords: therapy; dtmp; radiation; injury ... See more keywords
A Novel Reactive Current Injection (RCI) Control for Microgrid Protection with Inverter Based Distributed Generation (IBDG)
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DOI: 10.3390/en12173371
Abstract: As the development of renewable distributed generations (DGs) is growing rapidly, the autonomous self-healing microgrid had emerged as an effective solution for integrating renewable DGs in the distribution networks. However, before the autonomous self-healing microgrid… read more here.
Keywords: protection; rci; control; inverter based ... See more keywords