Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-022-00935-x
Abstract: Dear Editor, Inherited and age-related retinal degenerative diseases cause progressive loss of photoreceptors, ultimately leading to blindness. Optogenetics is a promising strategy for restoring visual function through photosensitive proteins’ ectopic expression in surviving retinal neurons.… read more here.
Keywords: mice; visual function; pscatch2; rd1 mice ... See more keywords
Expression of exogenous PDE5 rescues photoreceptors in rd1 mice.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220216111952
Abstract: BACKGROUND Catalytic hydrolysis of cyclic guanosine monophosphate (cGMP) by phosphodiesterase 6 (PDE6) is a critical step in phototransduction signalling in photoreceptors. Mutations in the genes encoding any of the three PDE6 subunits are associated with… read more here.
Keywords: expression; rd1 mice; photoreceptors rd1; pde5 ... See more keywords