A computational comparative analysis of the binding mechanism of molnupiravir's active metabolite to RNA‐dependent RNA polymerase of wild‐type and Delta subvariant AY.4 of SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30226
Abstract: The antiviral drug molnupiravir targets the SARS‐CoV‐2 RNA‐dependent RNA polymerase (RdRP) enzyme. Early treatment with molnupiravir reduced the risk of hospitalization or death in at‐risk, unvaccinated adults with COVID‐19, according to phase 3 clinical trials.… read more here.
Keywords: dependent rna; rna polymerase; rdrp; rna ... See more keywords
Development and characterization of a new monoclonal antibody against SARS‐CoV‐2 NSP12 (RdRp)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28246
Abstract: SARS‐CoV‐2 NSP12, the viral RNA‐dependent RNA polymerase (RdRp), is required for viral replication and is a therapeutic target to treat COVID‐19. To facilitate research on SARS‐CoV‐2 NSP12 protein, we developed a rat monoclonal antibody (CM12.1)… read more here.
Keywords: cov nsp12; monoclonal antibody; rdrp; sars cov ... See more keywords
Bovine lactoferrin inhibits SARS‐CoV‐2 and SARS‐CoV‐1 by targeting the RdRp complex and alleviates viral infection in the hamster model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28281
Abstract: Breast milk has been found to inhibit coronavirus infection, while the key components and mechanisms are unknown. We aimed to determine the components that contribute to the antiviral effects of breastmilk and explore their potential… read more here.
Keywords: blf; infection; rdrp; coronavirus ... See more keywords
Interaction of the intrinsically disordered C-terminal domain of the sesbania mosaic virus RNA-dependent RNA polymerase with the viral protein P10 in vitro: modulation of the oligomeric state and polymerase activity
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Virology"
DOI: 10.1007/s00705-019-04163-7
Abstract: The RNA-dependent RNA polymerase (RdRp) of sesbania mosaic virus (SeMV) was previously shown to interact with the viral protein P10, which led to enhanced polymerase activity. In the present investigation, the equilibrium dissociation constant for… read more here.
Keywords: rdrp; polymerase activity; polymerase; p10 ... See more keywords
Repurposing nonnucleoside antivirals against SARS-CoV2 NSP12 (RNA dependent RNA polymerase): In silico-molecular insight
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2021.07.050
Abstract: The pandemic of SARS-CoV-2 has necessitated expedited research efforts towards finding potential antiviral targets and drug development measures. While new drug discovery is time consuming, drug repurposing has been a promising area for elaborate virtual… read more here.
Keywords: rdrp; rna dependent; rna; rna polymerase ... See more keywords
Nucleolin interacts with the rabbit hemorrhagic disease virus replicase RdRp, nonstructural proteins p16 and p23, playing a role in virus replication
Sign Up to like & getrecommendations! Published in 2022 at "Virologica Sinica"
DOI: 10.1016/j.virs.2022.01.004
Abstract: Rabbit hemorrhagic disease virus (RHDV) is a member of the Caliciviridae family and cannot be propagated in vitro, which has impeded the progress of investigating its replication mechanism. Construction of an RHDV replicon system has… read more here.
Keywords: rabbit hemorrhagic; rdrp; virus; host ... See more keywords
Design, Synthesis, and Antiviral Activity of 8‑Aza Fluoroneplanocin Derivatives Targeting SAH Hydrolase and Viral RdRp.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.5c00463
Abstract: RNA viruses such as SARS-CoV-2 and dengue virus pose global health threats, highlighting the urgent need for broad-spectrum antivirals with improved safety. We synthesized 8-aza Fluoroneplanocin derivatives designed to reduce cytotoxicity while maintaining antiviral potency.… read more here.
Keywords: fluoroneplanocin derivatives; fluoroneplanocin; rdrp; aza fluoroneplanocin ... See more keywords
Binding Mechanism of the Active Form of Molnupiravir to RdRp of SARS-CoV-2 and Designing Potential Analogues: Insights from Molecular Dynamics Simulations
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DOI: 10.1021/acsomega.4c05469
Abstract: Molnupiravir, an FDA-approved nucleoside prodrug for treating COVID-19, converts into N4-hydroxycytidine triphosphate (NHC-TP), which integrates into SARS-CoV-2 RNA by its RNA-dependent RNA polymerase (RdRp) causing lethal mutations in viral proteins. Due to the risk of… read more here.
Keywords: sars cov; dynamics simulations; rdrp; molecular dynamics ... See more keywords
RNA Editing with Viral RNA-Dependent RNA Polymerase.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00332
Abstract: RNA editing is currently attracting attention as a method for editing genetic information without injury to the genome. The most common approach to edit RNA sequences involves the induction of an A-to-I change by adenosine… read more here.
Keywords: rna editing; dependent rna; rna polymerase; rdrp ... See more keywords
Sequence-controlled polymers via reversible-deactivation radical polymerization
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DOI: 10.1038/pj.2017.66
Abstract: The development of reversible-deactivation radical polymerization (RDRP) has made a great contribution not only in controlling the molecular weight and terminal structures but also in the precise synthesis of copolymers. An additional design for controlled… read more here.
Keywords: rdrp; reversible deactivation; deactivation radical; radical polymerization ... See more keywords
In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22303-y
Abstract: Human norovirus causes approximately 219,000 deaths annually, yet there are currently no antivirals available. A virtual screening of commercially available drug-like compounds (~300,000) was performed on the suramin and PPNDS binding-sites of the norovirus RNA-dependent… read more here.
Keywords: rdrp; norovirus; human norovirus; inhibition ... See more keywords