Liver injury in remdesivir-treated COVID-19 patients
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology International"
DOI: 10.1007/s12072-020-10077-3
Abstract: Novel Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection results predominantly in pulmonary involvement (Coronavirus disease 2019, COVID-19), but a direct, SARS-CoV-2-induced liver damage has also been described [1, 2]. Thus, it is important to… read more here.
Keywords: covid patients; rdv; disease; injury ... See more keywords
Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-00537-9
Abstract: Remdesivir (RDV) exerts anti-severe acute respiratory coronavirus 2 activity following metabolic activation in the target tissues. However, the pharmacokinetics and tissue distributions of the parent drug and its active metabolites have been poorly characterized to… read more here.
Keywords: rdv; nucleotide monophosphate; triphosphate; remdesivir ... See more keywords
72. Remdesivir vs Standard Care in Patients with Moderate covid-19
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa439.382
Abstract: Background: Remdesivir (RDV) shortens time to recovery time in patients with severe COVID-19 Its effect in patients with moderate COVID-19 remains unclear Methods: We conducted an open-label, phase 3 trial (NCT04252664) involving hospitalized patients with… read more here.
Keywords: 10d rdv; rdv; moderate covid; patients moderate ... See more keywords
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abl8282
Abstract: Remdesivir (RDV) is a nucleotide analog prodrug with demonstrated clinical benefit in patients with coronavirus disease 2019 (COVID-19). In October 2020, the U.S. FDA approved intravenous RDV as the first treatment for hospitalized COVID-19 patients.… read more here.
Keywords: sars cov; inhalation; inhaled remdesivir; remdesivir ... See more keywords
Genetic Study of SARS-CoV-2 Non Structural Protein 12 in COVID-19 Patients Non Responders to Remdesivir
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DOI: 10.1128/spectrum.02448-22
Abstract: This study provides clinical and microbiologic data of an extended population of hospitalized patients for COVID-19 pneumonia who experienced treatment failure, detected by the presence of subgenomic RNA (sgRNA). The genetic variants found in the… read more here.
Keywords: health; rdv; rna; covid ... See more keywords
P35 Remdesivir in a pre-term neonate – was it worth it?
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DOI: 10.1136/archdischild-2023-nppg.34
Abstract: Background Situation On day 24 of life, a pre-term neonate (GA at birth 31+2 weeks) with achondroplasia tested SARS-CoV-2 positive on PCR. The patient was ventilated for increasing oxygen requirements, eventually necessitating transfer to the… read more here.
Keywords: rdv; pre term; remdesivir; decision ... See more keywords
Bradyarrhythmia After Remdesivir Administration in SARS-CoV-2: A Review of Literature and Meta-Analysis of Observational Studies in Epidemiology
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DOI: 10.14740/cr1377
Abstract: Background The coronavirus disease 2019 (COVID-19) pandemic has required timely and informed decisions about treatment recommendations for clinical practice. One such drug used for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection… read more here.
Keywords: rdv; meta analysis; observational studies; bradyarrhythmia ... See more keywords
Evidence for the Effectiveness of Remdesivir (GS-5734), a Nucleoside-Analog Antiviral Drug in the Inhibition of I K(M) or I K(DR) and in the Stimulation of I MEP
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01091
Abstract: Remdesivir (RDV, GS-5734), a broad-spectrum antiviral drug in the class of nucleotide analogs, has been particularly tailored for treatment of coronavirus infections. However, to which extent RDV is able to modify various types of membrane… read more here.
Keywords: antiviral drug; rdv; inhibition; remdesivir ... See more keywords