Tuning Recombinant Perlecan Domain V to Regulate Angiogenic Growth Factors and Enhance Endothelialization of Electrospun Silk Vascular Grafts
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DOI: 10.1002/adhm.202400855
Abstract: Synthetic vascular grafts are used to bypass significant arterial blockage when native blood vessels are unsuitable, yet their propensity to fail due to poor blood compatibility and progressive graft stenosis remains an intractable challenge. Perlecan… read more here.
Keywords: vascular grafts; perlecan domain; rdv; angiogenic growth ... See more keywords
Liver injury in remdesivir-treated COVID-19 patients
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology International"
DOI: 10.1007/s12072-020-10077-3
Abstract: Novel Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection results predominantly in pulmonary involvement (Coronavirus disease 2019, COVID-19), but a direct, SARS-CoV-2-induced liver damage has also been described [1, 2]. Thus, it is important to… read more here.
Keywords: covid patients; rdv; disease; injury ... See more keywords
Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-00537-9
Abstract: Remdesivir (RDV) exerts anti-severe acute respiratory coronavirus 2 activity following metabolic activation in the target tissues. However, the pharmacokinetics and tissue distributions of the parent drug and its active metabolites have been poorly characterized to… read more here.
Keywords: rdv; nucleotide monophosphate; triphosphate; remdesivir ... See more keywords
A replication-deficient gammaherpesvirus vaccine protects mice from lytic disease and reduces latency establishment
Sign Up to like & getrecommendations! Published in 2024 at "NPJ Vaccines"
DOI: 10.1038/s41541-024-00908-x
Abstract: Gammaherpesviruses are oncogenic viruses that establish lifelong infections and are significant causes of morbidity and mortality. Vaccine strategies to limit gammaherpesvirus infection and disease are in development, but there are no FDA-approved vaccines for Epstein-Barr… read more here.
Keywords: replication; gammaherpesvirus; disease; replication deficient ... See more keywords
72. Remdesivir vs Standard Care in Patients with Moderate covid-19
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa439.382
Abstract: Background: Remdesivir (RDV) shortens time to recovery time in patients with severe COVID-19 Its effect in patients with moderate COVID-19 remains unclear Methods: We conducted an open-label, phase 3 trial (NCT04252664) involving hospitalized patients with… read more here.
Keywords: 10d rdv; rdv; moderate covid; patients moderate ... See more keywords
Efficacy and safety of early administration of remdesivir in hemodialysis patients with COVID-19: A case report and literature review
Sign Up to like & getrecommendations! Published in 2024 at "Medicine"
DOI: 10.1097/md.0000000000040650
Abstract: Rationale: Although the mortality of severe coronavirus disease 2019 (COVID-19) has decreased after the emergence of the Omicron variant, it remains high in patients on hemodialysis (HD). Remdesivir (RDV) is considered as the first line… read more here.
Keywords: covid; administration; rdv; literature review ... See more keywords
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abl8282
Abstract: Remdesivir (RDV) is a nucleotide analog prodrug with demonstrated clinical benefit in patients with coronavirus disease 2019 (COVID-19). In October 2020, the U.S. FDA approved intravenous RDV as the first treatment for hospitalized COVID-19 patients.… read more here.
Keywords: sars cov; inhalation; inhaled remdesivir; remdesivir ... See more keywords
Population pharmacokinetics of ravidasvir in adults with chronic hepatitis C virus infection and impact of antiretroviral treatment
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DOI: 10.1128/aac.00008-24
Abstract: ABSTRACT Ravidasvir (RDV) is a novel NS5A inhibitor that exhibits potent pan-genotypic inhibition of hepatitis C virus (HCV) replication. Sofosbuvir (SOF) plus RDV was demonstrated to be efficacious and safe in adults with active HCV… read more here.
Keywords: treatment; hepatitis virus; rdv; population ... See more keywords
Genetic Study of SARS-CoV-2 Non Structural Protein 12 in COVID-19 Patients Non Responders to Remdesivir
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DOI: 10.1128/spectrum.02448-22
Abstract: This study provides clinical and microbiologic data of an extended population of hospitalized patients for COVID-19 pneumonia who experienced treatment failure, detected by the presence of subgenomic RNA (sgRNA). The genetic variants found in the… read more here.
Keywords: health; rdv; rna; covid ... See more keywords
P35 Remdesivir in a pre-term neonate – was it worth it?
Sign Up to like & getrecommendations! Published in 2023 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2023-nppg.34
Abstract: Background Situation On day 24 of life, a pre-term neonate (GA at birth 31+2 weeks) with achondroplasia tested SARS-CoV-2 positive on PCR. The patient was ventilated for increasing oxygen requirements, eventually necessitating transfer to the… read more here.
Keywords: rdv; pre term; remdesivir; decision ... See more keywords
Safety evaluation of remdesivir administration in patients with severe renal impairment and coronavirus disease: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2025 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-025-11153-5
Abstract: We conducted a comprehensive systematic review and meta-analysis to evaluate whether remdesivir (RDV) is safe for patients with severe renal impairment (SRI) and COVID-19, compared to non-SRI patients or those not receiving RDV. This study… read more here.
Keywords: rdv; meta analysis; sri; sri patients ... See more keywords