Gold catalyzed cascade reaction of 2-Alkynyl arylazides with 1,2,3-Triazoles to provide N- and N-Indol-3-yl 1,2,3-Triazole derivatives
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DOI: 10.1016/j.tetlet.2020.151851
Abstract: Abstract A new method was developed to prepare N1 and N2-indol-3-yl 1,2,3-trizole products through gold catalyzed cascade reaction of o-alkynyl arylazides with 1,2,3-triazoles, in which, the in-situ generated α-imino gold carbene intermediate was intercepted by… read more here.
Keywords: cascade reaction; arylazides triazoles; reaction alkynyl; catalyzed cascade ... See more keywords
Silver(I)-Mediated Cascade Reaction of 2-(1-Alkynyl)-2-alken-1-ones with 2-Naphthols.
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DOI: 10.1021/acs.orglett.0c01803
Abstract: An efficient cascade reaction of 2-(1-alkynyl)-2-alken-1-ones with 2-naphthols promoted by silver trifluoroacetate is disclosed, providing an expeditious access to 1,2-dihydronaphtho[2,1-b]furans with moderate to good yields. This domino process involves highly regio- and diastereoselective sequential cyclization/nucleophilic… read more here.
Keywords: ones naphthols; alken ones; cascade reaction; alkynyl alken ... See more keywords
Gold-Catalyzed Cascade Reaction of 2-Alkynyl Aryl Azides with Enecarbamates for Direct Synthesis of α-(3-Indolyl)ketones.
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DOI: 10.1021/acs.orglett.2c04147
Abstract: α-(3-Indolyl)ketones are essential building blocks for the generation of biologically active molecules. We described a new method for the direct assembly of α-(3-indolyl)ketones through the cascade reaction of 2-alkynyl aryl azides with enecarbamates, in which… read more here.
Keywords: aryl azides; azides enecarbamates; reaction alkynyl; cascade reaction ... See more keywords
One-step synthesis of benzo[b]thiophenes by aryne reaction with alkynyl sulfides†
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DOI: 10.1039/d0sc04450d
Abstract: An aryne reaction with alkynyl sulfides affording benzo[b]thiophenes is disclosed. A wide range of 3-substituted benzothiophenes were synthesized from easily available o-silylaryl triflates and alkynyl sulfides in a one-step intermolecular manner. The synthesis of diverse… read more here.
Keywords: aryne reaction; alkynyl sulfides; one step; reaction alkynyl ... See more keywords
Transposition of an acrylate moiety in TMSOTf-mediated reaction of alkynyl vinylogous carbonates gives heterocyclic dienes.
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DOI: 10.1039/d2cc03802a
Abstract: TMSOTf-mediated reaction of alkynyl vinylogous carbonates serendipitously gave 1,4-oxazepine and dihydropyran dienes via transposition of an ethyl acrylate moiety involving intramolecular cascade Prins-type cyclization/retro-oxa-Michael reaction/cycloisomerisation. The developed atom-economical protocol selectively provides an E double bond… read more here.
Keywords: reaction; mediated reaction; alkynyl vinylogous; reaction alkynyl ... See more keywords