Tuning the Diels-Alder Reaction for Bioconjugation to Maleimide Drug-Linkers.
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DOI: 10.1021/acs.bioconjchem.8b00320
Abstract: The thiol-maleimide linkage is widely used for antibody-drug conjugate (ADC) production; however, conjugation of maleimide-drugs could be improved by simplified procedures and reliable conjugate stability. Here, we report the evaluation of electron-rich and cyclic dienes… read more here.
Keywords: diels alder; reaction bioconjugation; drug; reaction ... See more keywords