Catalytic Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Umpolung Cross-Mannich Reaction of Cyclic Ketimines.
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DOI: 10.1021/acs.orglett.0c01578
Abstract: A catalytic asymmetric umpolung cross-Mannich reaction of cyclic ketimines is realized. This protocol provides an efficient methodology for the facile synthesis of chiral vicinal tetrasubstituted diamines in high yields with excellent chemo-, regio-, diastereo-, and… read more here.
Keywords: mannich reaction; reaction cyclic; cyclic ketimines; umpolung cross ... See more keywords
Synthesis of 4-substituted 3-(2-hydroxyphenyl)-quinolines through an unexpected iron(III) chloride promoted reaction of cyclic imine dibenzo[b,f][1,4]oxazepines with alkynes
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DOI: 10.1039/c6qo00545d
Abstract: An unexpected FeCl3-promoted reaction of cyclic imine dibenzo[b,f][1,4]oxazepines with alkynes was studied, leading to a series of 4-substituted 3-(2-hydroxyphenyl)-quinolines. A variety of substituted cyclic imines and terminal alkynes (arylacetylenes, conjugated enynes, and 1,3-diynes) were used… read more here.
Keywords: substituted hydroxyphenyl; imine dibenzo; promoted reaction; cyclic imine ... See more keywords
Synthesis of N-Aryl-4-arylhexahydroquinoline Derivatives by Reaction of Cyclic Enaminones with Arylidenemalononitriles in DMSO
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DOI: 10.1055/s-0040-1705984
Abstract: The reaction of cyclic enaminones with arylidenemalononitriles was carried out in the presence of 13X molecular sieves in dimethyl sulfoxide. Under these mild reaction conditions, various bioactive N-aryl-4-arylhexahydroquinoline derivatives were obtained in high yields without… read more here.
Keywords: arylhexahydroquinoline derivatives; reaction cyclic; cyclic enaminones; aryl arylhexahydroquinoline ... See more keywords