Regioselective alkylation reaction of the 2′-deoxyctidine with 9-aminomethyl derivatives of SN38
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DOI: 10.1016/j.molstruc.2018.08.096
Abstract: Abstract We present first evidence of a spontaneous alkylation of the 2′-deoxycytidine by potential topoisomerase I inhibitors from camptothecins family. The 7-ethyl-9-(N-morpholino)methyl-10-hydroxycamptothecin and the 7-ethyl-9-(N-pyrrolidinyl)methyl-10-hydoxycamptothecin regioselectively alkylate spontaneously an exo-cyclic nitrogen (N4) of the 2′-… read more here.
Keywords: regioselective alkylation; alkylation; alkylation reaction; reaction ... See more keywords