Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine
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DOI: 10.1021/acs.jmedchem.1c02214
Abstract: The SARS-CoV-2 main protease (Mpro) is a medicinal chemistry target for COVID-19 treatment. Given the clinical efficacy of β-lactams as inhibitors of bacterial nucleophilic enzymes, they are of interest as inhibitors of viral nucleophilic serine… read more here.
Keywords: penicillin derivatives; chemistry; reaction nucleophilic; cov main ... See more keywords