Metabolite Profiling and Reaction Phenotyping for the in vitro Assessment of the Bioactivation of Bromfenac.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00268
Abstract: Bromfenac is a non-steroidal anti-inflammatory drug that was approved and subsequently withdrawn from the market due to reported cases of acute hepatotoxicity. Recently, in vitro studies have revealed that bromfenac requires UDPGA and alamethicin supplemented… read more here.
Keywords: profiling reaction; bioactivation; metabolite profiling; bromfenac ... See more keywords
Metabolite profiling and enzyme reaction phenotyping of luseogliflozin, a sodium–glucose cotransporter 2 inhibitor, in humans
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DOI: 10.1080/00498254.2016.1193263
Abstract: Abstract 1. To understand the clearance mechanism of luseogliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, we investigated its human metabolite profile and metabolic enzymes responsible for the primary metabolic pathways in human using reaction phenotyping. 2. Sixteen… read more here.
Keywords: luseogliflozin sodium; sodium glucose; form; glucose cotransporter ... See more keywords
Reaction phenotyping to assess victim drug-drug interaction risks
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2017.1367280
Abstract: ABSTRACT Introduction: Reaction phenotyping provides critical information regarding the fraction metabolized (fm) of drug candidates. It has become increasingly important in drug discovery and development as it can be used to assess victim drug-drug interaction… read more here.
Keywords: assess victim; reaction phenotyping; victim drug; drug ... See more keywords
An Improved Method for Cytochrome P450 Reaction Phenotyping Using a Sequential Qualitative-Then-Quantitative Approach
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.000883
Abstract: Cytochrome P450 reaction phenotyping to determine the fraction of metabolism (fm) values for individual enzymes is a standard study in the evaluation of a new drug. However, there are technical challenges in these studies caused… read more here.
Keywords: step; reaction phenotyping; p450 reaction; drug ... See more keywords