An enyne cycloisomerization/[5+1] reaction sequence to synthesize tetrahydroisoquinolinones from enyne-enes and CO.
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DOI: 10.1039/c6cc09925d
Abstract: An enyne cycloisomerization/[5+1] reaction sequence was developed to synthesize tetrahydroisoquinolinones from linear enyne-enes and CO. The first step is a gold(i)-catalyzed enyne cycloisomerization, generating six-membered-ring-fused vinylcyclopropanes. The second step is a rhodium(i)-catalyzed [5+1] reaction of… read more here.
Keywords: enyne cycloisomerization; cycloisomerization; reaction; reaction sequence ... See more keywords
Is the reaction sequence in phosphine-catalyzed [8+2] cycloaddition controlled by electrophilicity?
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc07370a
Abstract: In the presence of multiple electrophiles, the reaction sequence is a critical mechanistic problem. Here, we report a theoretical study on the mechanism of phosphine-catalyzed [8+2] cycloaddition of heptafulvenes and allenoate. DFT calculations showed that… read more here.
Keywords: phosphine catalyzed; catalyzed cycloaddition; reaction sequence;