Different Reaction Specificities of F420H2-Dependent Reductases Facilitate Pyrrolobenzodiazepines and Lincomycin to Fit Their Biological Targets.
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DOI: 10.1021/jacs.9b11234
Abstract: Lincosamide antibiotics, antitumor pyrrolobenzodiazepines (PBDs), quorum-sensing molecule hormaomycin, and antimicrobial griselimycin are structurally and functionally diverse groups of actinobacterial metabolites. The common feature of these metabolites is the incorporation of L-tyrosine- or L-leucine-derived 4-alkyl-L-proline derivatives… read more here.
Keywords: different reaction; reaction specificities; f420h2 dependent; biological targets ... See more keywords