Enantioselective Construction of Consecutive Tetrasubstituted Stereogenic Centers by Reaction of α-Substituted β-Nitroacrylates with Oxazol-5-(4H)-ones Catalyzed by Cinchona Alkaloid Sulfonamide Catalysts.
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DOI: 10.1021/acs.orglett.3c00783
Abstract: The enantioselective reaction of α-substituted β-nitroacrylates with oxazol-5-(4H)-ones (oxazolones) to construct consecutive tetrasubstituted stereogenic centers was accomplished. A cinchona alkaloid sulfonamide catalyst afforded products bearing vicinal chiral centers with excellent enantio- and diastereoselectivities. The obtained… read more here.
Keywords: consecutive tetrasubstituted; reaction substituted; substituted nitroacrylates; reaction ... See more keywords
Access to quinolinones via DMAP-catalysed cascade reaction of 2-substituted benzoic acids with organic azides.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04406d
Abstract: Herein, we report a DMAP-catalysed Curtius rearrangement and intramolecular cyclisation cascade reaction of 2-substituted aryl carboxylic acids with organic azides for the first time. This protocol features simple operation, broad scope and metal-free conditions, furnishing… read more here.
Keywords: acids organic; reaction substituted; reaction; dmap catalysed ... See more keywords