Gold(III) or Gold(I)/Lewis-Acid-Catalyzed Substitution/Cyclization/1,2-Migration Reactions of Propargyl Alcohols with 3-Amino-benzo[d]isoxazoles: Synthesis of Pyrimidine Derivatives.
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DOI: 10.1021/acs.orglett.2c01011
Abstract: A straightforward synthesis of pyrimidines via Au(III) or Au(I)/Lewis-acid-catalyzed cascade reactions of propargyl alcohols with 3-amino-benzo[d]isoxazoles is described. The propargyl amine intermediates are readily generated in situ via oxophilic activation of gold(III) or a Lewis… read more here.
Keywords: reactions propargyl; propargyl alcohols; acid; alcohols amino ... See more keywords
Metal-free trans-hydroboration without a B-H bond: reactions of propargyl amines with Lewis acidic boranes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02687b
Abstract: The first alkyne trans-hydroboration reaction without a B-H bond was described. This was achieved by reactions of propargyl amines with Lewis acidic boranes under mild conditions. The mechanism involved borane-mediated alkyne activation and intramolecular hydride… read more here.
Keywords: reactions propargyl; without bond; propargyl amines; trans hydroboration ... See more keywords