Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
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DOI: 10.1016/j.cell.2018.09.051
Abstract: Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through RNAPII pause release. We now report that CDK9 is also essential for maintaining gene silencing at heterochromatic loci. Through a live cell drug screen with genetic confirmation,… read more here.
Keywords: reactivates epigenetically; cdk9; genes cancer; cancer ... See more keywords