Acetaldehyde Dehydrogenase 2(ALDH2) in Atherosclerosis: Beyond Detoxification of Reactive Aldehydes
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.191
Abstract: Previous studies have linked human polymorphisms of ALDH2 to cardiovascular diseases but the underlying mechanisms remain elusive. Here we investigated the role of ALDH2 in atherosclerosis using a murine model of low density lipoprotein receptor… read more here.
Keywords: acetaldehyde dehydrogenase; aldh2 atherosclerosis; atherosclerosis; detoxification reactive ... See more keywords
Analysis of reactive aldehydes in urine and plasma of type-2 diabetes mellitus patients through liquid chromatography-mass spectrometry: Reactive aldehydes as potential markers of diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.997015
Abstract: Introduction Diabetes is a major public health issue that is approaching epidemic proportions globally. Diabetes mortality is increasing in all ethnic groups, irrespective of socio-economic class. Obesity is often seen as the main contributor to… read more here.
Keywords: reactive aldehydes; liquid chromatography; oxidative stress; plasma ... See more keywords
A Computational Insight into Reaction Between Different Amino Acids with Reactive Aldehydes 4-hydroxy-2-nonenal and 4-oxo-2-nonenal
Sign Up to like & getrecommendations! Published in 2019 at "Croatica chemica acta"
DOI: 10.5562/cca3579
Abstract: In this work, we studied in detail the reaction mechanism of modification of arginine (Arg), cysteine (Cys) and histidine (His) model amino acids upon the reaction with biologically relevant reactive aldehydes 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal… read more here.
Keywords: amino; amino acids; hydroxy nonenal; reaction ... See more keywords