Tumor-reactive antibodies evolve from non-binding and autoreactive precursors
Sign Up to like & getrecommendations! Published in 2022 at "Cell"
DOI: 10.1016/j.cell.2022.02.012
Abstract: The tumor microenvironment hosts antibody-secreting cells (ASCs) associated with a favorable prognosis in several types of cancer. Patient-derived antibodies have diagnostic and therapeutic potential; yet, it remains unclear how antibodies gain autoreactivity and target tumors.… read more here.
Keywords: tumor; evolve non; reactive antibodies; tumor reactive ... See more keywords
Changes in concentrations of tau-reactive antibodies are dependent on sex in Alzheimer's disease patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2018.05.004
Abstract: The presence of pre-existing natural antibodies against Alzheimer's disease (AD) pathological proteins might interfere with immune responses to therapeutic vaccination with these proteins. We aimed to compare levels of antibodies in CSF and serum: We… read more here.
Keywords: reactive antibodies; tau reactive; alzheimer disease; antibodies dependent ... See more keywords
Presence of Panel-reactive Antibodies after Penetrating Keratoplasty
Sign Up to like & getrecommendations! Published in 2022 at "Ocular Immunology and Inflammation"
DOI: 10.1080/09273948.2022.2060263
Abstract: ABSTRACT Purpose To evaluate the relationship between penetrating keratoplasty (PK) and postoperative PRA level and number of unacceptable antigens. Methods A cross-sectionalstudy was performed on patients with history of PK. Patients with prior solid organ… read more here.
Keywords: pra level; reactive antibodies; pra; panel reactive ... See more keywords
Portuguese calculated panel reactive antibodies online estimator
Sign Up to like & getrecommendations! Published in 2019 at "HLA"
DOI: 10.1111/tan.13516
Abstract: Calculated panel reactive antibodies (CPRA) is a sensitization measure used to classify and prioritize transplant candidates in different kidney transplant allocation systems. CPRA is based on identification of HLA unacceptable on potential organ donors making… read more here.
Keywords: reactive antibodies; cpra; calculated panel; online estimator ... See more keywords
Cross-Reactive Antibody Responses against Nonpoliovirus Enteroviruses
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DOI: 10.1128/mbio.03660-21
Abstract: Enteroviruses (EVs) are common human pathogens. Although infection with EVs leads to cross-reactive antibodies, the clinical relevance of these antibodies is unclear given the estimated incidence of EV infections in the general population of one… read more here.
Keywords: common human; reactive antibodies; infection; nonpoliovirus enteroviruses ... See more keywords
Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion Peptide
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.790415
Abstract: To face the continuous emergence of SARS-CoV-2 variants, broadly protective therapeutic antibodies are highly needed. We here focused on the fusion peptide (FP) region of the viral spike antigen since it is highly conserved among… read more here.
Keywords: reactive antibodies; fusion peptide; coronavirus; cross reactive ... See more keywords
Two Opposing Roles of SARS-CoV-2 RBD-Reactive Antibodies in Pre-Pandemic Plasma Samples From Elderly People in ACE2-Mediated Pseudovirus Infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.813240
Abstract: A novel coronavirus designated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged and caused an outbreak of unusual viral pneumonia. Several reports have shown that cross-reactive antibodies against SARS-CoV-2 also exist in people unexposed to… read more here.
Keywords: reactive antibodies; rbd reactive; plasma samples; infection ... See more keywords
Pre-existing humoral immunity to low pathogenic human coronaviruses exhibits limited cross-reactive antibodies response against SARS-CoV-2 in children
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1042406
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes asymptomatic or mild symptoms, even rare hospitalization in children. A major concern is whether the pre-existing antibodies induced by low pathogenic human coronaviruses (LPH-CoVs) in children… read more here.
Keywords: lph covs; reactive antibodies; pre existing; cross reactive ... See more keywords
Prevalence of Orthohantavirus-Reactive Antibodies in Humans and Peri-Domestic Rodents in Northern Ethiopia
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13061054
Abstract: In 2012, Tigray orthohantavirus was discovered in Ethiopia, but its seasonal infection in small mammals, and whether it poses a risk to humans was unknown. The occurrence of small mammals, rodents and shrews, in human… read more here.
Keywords: northern ethiopia; reactive antibodies; prevalence; orthohantavirus reactive ... See more keywords
Induction of Broadly Cross-Reactive Antibodies by Displaying Receptor Binding Domains of SARS-CoV-2 on Virus-like Particles
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10020307
Abstract: The impact of the COVID-19 pandemic has been reduced since the application of vaccination programs, mostly shown in the reduction of hospitalized patients. However, the emerging variants, in particular Omicron, have caused a steep increase… read more here.
Keywords: sars cov; virus like; reactive antibodies; cov virus ... See more keywords